sabizabulin(Pending FDA approval)

Action and Spectrum

sabizabulin has a dual function, acting as both an anti-inflammatory and antiviral agent. Its mechanism involves disrupting microtubule filaments, which are integral to cellular structure and processes.

By binding to alpha and beta tubulin, it inhibits tubulin polymerization, impacting cell migration, cytokine release, and intracellular trafficking. This interference with microtubules plays a crucial role in hindering viral infection, including that of SARS-CoV-2, by disrupting processes essential for viral replication and spread. 

Drug Interaction

Adverse Reaction

Frequency defined 

N/A 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution: 

Contraindications: 

N/A 

Caution: 

N/A 

Pregnancy / Lactation

Pregnancy consideration: N/A 

Lactation: N/A 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

sabizabulin has a dual function, acting as both an anti-inflammatory and antiviral agent. Its mechanism involves disrupting microtubule filaments, which are integral to cellular structure and processes. By binding to alpha and beta tubulin, it inhibits tubulin polymerization, impacting cell migration, cytokine release, and intracellular trafficking. This interference with microtubules plays a crucial role in hindering viral infection, including that of SARS-CoV-2, by disrupting processes essential for viral replication and spread. 

Pharmacokinetics: 

N/A 

Adminstartion

Administration: 

N/A 

Patient Information Leaflet

Patient information leaflet 

Generic Name: sabizabulin 

Why do we use sabizabulin? 

sabizabulin is prescribed to hospitalised COVID-19 patients who are at high risk of developing acute respiratory distress syndrome (ARDS).