Brand Name :
Transderm Scop, Maldemar, Scopace
Synonyms :
hyoscine
Class :
Antiemetic agents; antimuscarinics
Brand Name :
Transderm Scop, Maldemar, Scopace
Synonyms :
hyoscine
Class :
Antiemetic agents; antimuscarinics
Dosage forms & Strengths
Transdermal patch
1mg/72 hr
0.3-0.65 mg intravenously, intramuscularly, and subcutaneously used for the treatment
Repeat every 6-8 hours if required
chemotherapy Induced Vomiting and Nausea
(Off-label)
Apply a patch every 72 hours in case of vomiting due to chemotherapy
Safety and efficacy are not seen in pediatric patients
Refer to the adult dosing
it increases the toxicity of scopolamine when used simultaneously
scopolamine and macimorelin interact with each other due to an unspecified reaction mechanism
they increase the toxicity of each other when used simultaneously
they increase the toxicity of each other due to pharmacodynamic synergism
they both increase the toxicity of each other when used in combination
scopolamine decreases the effect of secretin by antagonistic activity
antiemetics increase the hypotensive effect of apomorphine
antiemetics may enhance the serotonergic effect of serotonergic Agents
may enhance the effect of serotonergic agents
antiemetics increase the serotonergic effect of tramadol
it increases the toxicity of scopolamine due to pharmacodynamic synergism
it decreases the effect of scopolamine by antagonistic activity
it decreases the effect of scopolamine by antagonistic activity
scopolamine increases the effect of levodopa
Actions and Spectrum:
scopolamine is a medication that belongs to the class of drugs called anticholinergics. It has a broad spectrum of actions and treats various conditions.
Frequency defined
>10%
Dry mouth
Drowsiness
Dizziness
Blurred vision
Frequency not defined
Disorientation
Confusion
Pruritus and edema
Pupil dilation
Anticholinergic effects
Withdrawal symptoms
Contraindication/Caution:
scopolamine has several contraindications and cautions that must be considered before prescribing or using the medication. These include:
Pregnancy consideration:
scopolamine should not be used in pregnant females if they are suffering from preeclampsia
Breastfeeding warnings: no scientific data available for the effect of scopolamine on lactating females
Pregnancy category:
Pharmacology:
scopolamine is an anticholinergic medication that blocks the action of acetylcholine, a neurotransmitter that is involved in the regulation of various physiological processes in the body. Scopolamine acts on muscarinic receptors, which are found in various organs, including the brain, eyes, heart, lungs, gastrointestinal tract, and bladder.
Pharmacodynamics:
scopolamine is an anticholinergic drug that acts by inhibiting the binding of acetylcholine to muscarinic receptors in the body. This results in various pharmacodynamic effects, including:
Pharmacokinetics:
Absorption
Onset of action for intramuscular administration is 0.5-1 hr and for intravenous infusion is 10 min
Duration of action for intramuscular administration is 4-6 hours and for intravenous administration is 2 hours
Peak plasma concentration is achieved in 24 hours (transdermal)
Distribution
The volume of distribution of intravenous scopolamine is 141.3 ± 1.6 L.
Metabolism
The drug is metabolized in the liver by conjugation
Elimination and Excretion
The half-life is 9.5 hours
The drug is primarily excreted in urine, 90% in the form of metabolites
Administration:
scopolamine can be administered through various routes depending on the indication and the desired effect. These routes include:
The route of administration and the dose of scopolamine depend on the indication and the patient’s age and medical condition. scopolamine should be used with caution in elderly patients, as they may be more sensitive to the medication and may experience more side effects.
Patients should be advised to avoid activities that require mental alertness, such as driving or operating heavy machinery, after taking scopolamine. It is important to follow the instructions of a healthcare provider when taking scopolamine to avoid any adverse effects.
Patient information leaflet
Generic Name: scopolamine
Pronounced: sco-pol-am-ine
Why do we use scopolamine?
scopolamine is a medication that belongs to a class of drugs called anticholinergics. It primarily treats motion sickness, nausea, vomiting, and dizziness associated with inner ear problems.
scopolamine is also used in some medical procedures, such as surgeries, to prevent excessive salivation and respiratory secretions. In addition, it can be used as a pre-anesthetic medication to reduce anxiety and induce sedation before surgery.
Furthermore, scopolamine has been used recreationally as a “date rape drug” because it can cause sedation, confusion, and memory loss when mixed with alcohol or other drugs. However, this use is illegal and highly dangerous.
It is important to note that scopolamine can have serious side effects and should only be used under the guidance of a healthcare professional.