secalciferol

Action and Spectrum

Actions and spectrum:

Secalciferol is an essential hormone that plays a crucial role in the healing of fractured bone and has a physiological role in the metabolism of human bone and minerals, leading to enhanced synthesis of osteocalcin. Seclaciferol can bind the ligand binding domain to a nuclear protein VDR (vitamin D receptor). This binding triggers the inhibition of calcium channels and regulates calcium homeostasis.

Drug Interaction

Adverse Reaction

Adverse reactions

• Nausea
• Vomiting
• Increased urination
• Allergic reactions
• Kidney stones
• Weakness
• Hypercalcemia

Black Box Warning

Black box warning

No specific black box warning is available

Contraindication / Caution

Contraindications/Caution

Hypercalcemia

Hypersensitivity

Pregnancy / Lactation

Pregnancy & breastfeeding:

Pregnancy consideration:

Safety and efficacy data about the use of secalciferol in pregnancy is not known.

Breastfeeding warnings:

Data about the excretion of the drug into human milk is not known

Pregnancy categories:

• Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
• Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
• Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
• Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
• Category N: No data for the drug under this category is available.

Pharmacology

Pharmacology:

Secalciferol is the primary metabolite of vitamin D.

Pharmacodynamics:

In vitro studies suggest that treating with secalciferol reduced chondrogenic ATDC5 and increased the specific activity of alkaline phosphatase in a dose-related manner. It also reversed the Pi-induced apoptosis.

Pharmacokinetics:

Limited data available

Adminstartion

Administration:

Data about the administration of secalciferol is not available

Patient Information Leaflet

Patient information leaflet

Generic Name: secalciferol

Pronounced: sea-kal-si-phae-role

Why do we use secalciferol?

Secalciferol is involved in proliferation, calcium homeostasis, and cellular differentiation, along with various immune system functions. It is indicated in treating disorders due to phosphor and calcium homeostasis. It is also a marker in the catabolism of vitamin D3. This drug also helps heal fractured bones and osteoporosis.