secobarbital

medtigo

secobarbital

Brand Name :

Seconal

Synonyms :

secobarbital

Class :

Sedative/Hypnotics and Barbiturates

Action and Spectrum

Actions and Spectrum:

Actions:

Induces sleep
Relaxes muscles
Reduces anxiety
Produces a calming effect

Spectrum:

secobarbital is classified as a short-acting barbiturate, meaning it has a relatively short duration of action compared to other barbiturates.
It is used primarily for the treatment of insomnia but can also be used as a sedative before certain medical procedures.
It has a high potential for abuse and dependence and is not recommended for long-term use.
It should only be used under the supervision of a healthcare professional and should not be used in combination with other sedative medications or alcohol.

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency Not Defined

Ataxia

Dizziness

Constipation

Headache

Anxiety

Irritability

Hallucinations

Somnolence

Nightmares

Bleeding

Rash

Fever

Black Box Warning

Black Box Warning

Black box warning for secobarbital due to the risk of dependence, addiction, and overdose. The warning states that secobarbital should only be used for a short period of time (no longer than two to four weeks) and at the lowest effective dose.

Contraindication / Caution

Contraindication/Caution:

Contraindication:

secobarbital is contraindicated in individuals with a history of severe liver disease, as it can cause liver damage.
It is also contraindicated in individuals with a history of drug or alcohol abuse, as it can be habit-forming and lead to addiction.

Caution:

Caution should be used when administering secobarbital to individuals with a history of respiratory or lung disease, as it can cause respiratory depression.
It should also be used with caution in individuals with a history of depression or suicidal thoughts, as it can worsen these conditions.
Additionally, secobarbital should not be used with other central nervous system depressants, such as opioids or benzodiazepines, as this can increase the risk of respiratory depression and other side effects.
It should also not be used during pregnancy or breastfeeding, as it can cause harm to the developing fetus or infant.

Pregnancy / Lactation

Pregnancy warnings:   

US FDA pregnancy category: Not assigned

Lactation:

Excreted into human milk is known

Pregnancy Categories:     

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.  

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.  

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

secobarbital, a barbiturate, is a sedative and hypnotic drug.

It functions by enhancing GABA (gamma-aminobutyric acid) neurotransmitter activity in the brain. GABA controls nerve cell activity, which promotes calm and lowers anxiety. Pharmacodynamics:

When secobarbital is taken, it binds to specific receptors in the brain called GABA-A receptors. This binding causes a conformational change in the receptor, which leads to an influx of chloride ions into the neuron. This influx of ions makes the neuron more negatively charged and less likely to fire, leading to a decrease in neuronal activity and a decrease in overall brain activity.

Pharmacokinetics:

Absorption

It is rapidly absorbed from the gastrointestinal tract after oral administration. The peak plasma concentrations are reached within 1-2 hours

Distribution

It is widely distributed in the body, with a large volume of distribution. It is highly protein-bound, with an estimated binding of 96-98%

Metabolism

secobarbital is metabolized in the liver by hydroxylation and conjugation. The major metabolite is 5-ethyl-5-(1-methylbutyl) barbituric acid

Elimination and excretion

secobarbital is eliminated primarily by renal excretion, with a half-life of approximately 12-16 hours

Adminstartion

Administration:

Oral Administration

secobarbital is a barbiturate medication that is used as a sedative and hypnotic. It is administered orally, typically in capsule or tablet form. The dosage and frequency of administration will vary depending on the individual and the condition being treated.

Before administering secobarbital, it is important to assess the patient’s medical history and current medications to ensure that there are no contraindications or potential interactions. The patient should also be monitored for any adverse reactions or side effects, such as drowsiness, confusion, or respiratory depression.

Patient Information Leaflet

Patient information leaflet

Generic Name: secobarbital

Why do we use secobarbital?

secobarbital is used as a sedative and hypnotic to help individuals with insomnia, anxiety or tension. It works by slowing down the activity in the brain, which promotes relaxation and sleep. It is also used as a preoperative medication to help individuals relax and reduce anxiety before a surgical procedure. It can also be used to treat seizures, severe headaches and chronic pain.

secobarbital

No data available for drug.

DRUG INTERACTION

secobarbital

&

secobarbital +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

secobarbital

No data available for drug.

DRUG INTERACTION

secobarbital

&

secobarbital +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

secobarbital

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet