- March 15, 2022
- Newsletter
- 617-430-5616
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Brand Name :
Eldepryl, Zelapar
Synonyms :
Selegilinum, Selegilina, L-Deprenalin
Class :
Antidepressants and antianxiety drugs; MAO inhibitors
Dosage Forms & Strengths
Tablet
5mg
Capsule
5mg
Disintegrating tablet
1.25mg
Conventional-
5 mg orally at breakfast and 5 mg during lunch, hence; 10 mg/day
2-3 days later the selegiline therapy, taper the dose of levodopa by 10-30%, depending on the tolerance
Do not exceed the dose of more than 10 mg/day
If combined with levodopa, 1.25 mg orally each day
Orally-disintegrating-
Initially, 1.25 mg orally each day
If no adequate response is achieved, increase the dose after 6 weeks
Do not increase the dose to more than 2.5 mg/day
Don’t swallow
Take the medication in the morning without liquids
Dose Modifications
In the case of hepatic disease (mild to moderate), Child-Pugh class A & B- reduce the daily dose from 2.5 to 1.25 mg each day
Safety & efficacy is not seen in pediatrics
Dosage Forms & Strengths
Tablet
5mg
Capsule
5mg
Disintegrating tablet
1.25mg
5 mg orally every with each breakfast and lunch
When combined with levodopa, keep the dose less than 5 mg each day
3 days later of selegiline therapy, taper the dose of levodopa by 10-30%
Continue to streamline the dose as per the patient’s response
Orally-disintegrating-
Initially, 1.25 mg orally each day
If no adequate response is achieved, increase the dose after 6 weeks
Do not increase the dose to more than 2.5 mg/day
It may enhance serotonin levels when combined with tramadol
CNS depressants increase the CNS suppression effect of thalidomide
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
may increase the hypertension effect
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
May have an increased serotonergic effect when combined with Serotonin/Norepinephrine Reuptake Inhibitors
may have an increased serotonergic effect when combined with monoamine oxidase inhibitors
may have an increased serotonergic effect when combined with monoamine oxidase inhibitors
may have an increased serotonergic effect when combined with monoamine oxidase inhibitors
may have an increased serotonergic effect when combined with monoamine oxidase inhibitors
may have an increased serotonergic effect when combined with monoamine oxidase inhibitors
may increase the hypertensive effect
may increase the hypertensive effect
may increase the hypertensive effect
may increase the hypertensive effect
may increase the hypertensive effect
may increase the hypertensive effect
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
may have an increased serotonergic effect when combined with tricyclic antidepressants
it increases the effect of SSRIs
it increases the effect of SSRIs
it increases the effect of SSRIs
it increases the effect of SSRIs
it increases the effect of SSRIs
It may enhance the levels when combined with metformin by unspecified interactions mechanism
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
they increase the effect of Norepinephrine Reuptake Inhibitors
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
may have an increasingly adverse effect when combined with beta2-agonists
it increases the toxicity of diphenoxylate through an unknown mechanism
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of SSRIs
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of Norepinephrine Reuptake Inhibitors
it increases the effect of SSRIs
it increases the effect of Norepinephrine Reuptake Inhibitors
may enhance the effects of the other by pharmacodynamic synergism
may decrease the hypertensive effect of amphetamines
may increase the serotonergic effect of Dextromethorphan
may have an increasingly adverse effect when combined with isometheptene
