Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
N/A
Synonyms :
Seproxetine, (S)- norfluoxetine
Class :
Antidepressant/ SSRI (selective serotonin reuptake inhibitor)
Brand Name :
N/A
Synonyms :
Seproxetine, (S)- norfluoxetine
Class :
Antidepressant/ SSRI (selective serotonin reuptake inhibitor)
Dosage Forms & StrengthsÂ
It is discontinued due to cardiac side complicationsÂ
The medication’s development was never finished, and it was never marketed
It is discontinued due to cardiac side effects.
The medication's development was never finished, and it was never marketed
Dosage Forms & StrengthsÂ
Data not availableÂ
Refer to adult dosingÂ
the risk of hemorrhage may be increased
the rate of metabolism of abemaciclib may be reduced
the serum levels of acebutolol may be increased
the risk of gastrointestinal bleeding may be increased
the rate of metabolism of adagrasib may be reduced
the risk of adverse effects may be increased
the risk of gastrointestinal bleeding may be reduced
the rate of metabolism may be reduced
the risk of gastrointestinal bleeding may be increased
the CNS depressant activity of azelastine may be increased
the rate of metabolism of bedaquiline may be reduced
the rate of metabolism of bepridil may be reduced
the risk of hemorrhage may be increased
the risk of hemorrhage may be increased
Actions and spectrum:Â
Seproxetine, an active metabolite of fluoxetine, is a selective serotonin reuptake inhibitor. Â
Frequency not definedÂ
NauseaÂ
Excitation of CNSÂ
Do not drive vehicles or operate machinery
Contraindication/Caution:Â
Contraindication:Â
HypersensitivityÂ
Prolongation of QTÂ
Pregnancy consideration:Â Â
USFDA pregnancy category: safety and efficacy studies are not establishedÂ
Lactation:Â Â
Data about the excretion of seproxetine into breast milk is unknown Â
Pregnancy category:Â Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Seproxetine also known as (S)-norfluoxetine is the active metabolite of fluoxetine, a widely used antidepressant medication.Â
Pharmacodynamics:Â
Like fluoxetine, (S)-norfluoxetine acts as a selective serotonin reuptake inhibitor. The reuptake of serotonin (5-hydroxytryptamine or 5-HT) into presynaptic neurons is inhibited, leading to increased levels of serotonin in the synaptic cleft. This increased serotonin concentration is believed to contribute to the therapeutic effects of fluoxetine in the treatment of depression and other mood disorders.Â
Pharmacokinetics:Â
Limited information availableÂ
AbsorptionÂ
DistributionÂ
MetabolismÂ
Elimination and excretionÂ
Half-life:Â
4-16 days
Administer seproxetine as advised by the physicianÂ
Patient information leafletÂ
Generic Name: seproxetineÂ
Why do we use seproxetine?Â
Seproxetine is an antidepressant. It is a selective serotonin reuptake inhibitor. It is an active metabolite of fluoxetine.
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