serratiopeptidase

Action and Spectrum

Actions and spectrum: 

serratiopeptidase is an enzyme that has anti-inflammatory, analgesic, and fibrinolytic properties. It is derived from Serratia E15 bacteria and is known for its ability to dissolve and digest non-living tissue, such as blood clots, fibrin, and other protein accumulations in inflamed or damaged areas.

serratiopeptidase is used as a systemic enzyme to help reduce inflammation, improve pain, and support tissue repair. Its spectrum of action primarily involves its role in reducing inflammation and promoting the body’s natural healing processes. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Hypersensitivity 

Gastric discomfort 

Vomiting 

Diarrhoea 

Anorexia 

Nausea 

Epistaxis 

Skin rash 

Black Box Warning

Black Box Warning: 

There is no specific black box warning associated with serratiopeptidase. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Hypersensitivity: Individuals who have a known hypersensitivity or allergy to serratiopeptidase or any of its components should avoid its use. 
• Surgery: Due to its potential to affect blood clotting, it is advisable to stop using serratiopeptidase at least two weeks before any scheduled surgical procedures. Inform your surgeon about your serratiopeptidase use. 
• Peptic Ulcer Disease: serratiopeptidase might aggravate symptoms in individuals with active peptic ulcer disease or a history of such ulcers. 
• Children: serratiopeptidase may not be suitable for children unless prescribed by a healthcare provider. It is recommended for use in adults.

Caution: 

• Gastrointestinal Disorders: serratiopeptidase may cause gastrointestinal side effects such as stomach upset, nausea, or diarrhea in some individuals. If you have a history of gastrointestinal issues or peptic ulcer disease, use serratiopeptidase with caution. 
• Liver and Kidney Function: If you have impaired liver or kidney function, it is advisable to use serratiopeptidase cautiously, as there is a lack of extensive safety data in these populations. 
• Pregnancy and Breastfeeding: Limited safety information is available regarding the use of serratiopeptidase during pregnancy and while breastfeeding. It is advisable for pregnant and breastfeeding individuals to avoid its use unless prescribed by a healthcare professional.

Comorbidities: 

• Bleeding Disorders: serratiopeptidase has mild anticoagulant properties, which means it may reduce blood clotting. If you have bleeding disorders like hemophilia or are taking blood-thinning medications, consult your healthcare provider before using serratiopeptidase. 
• Gastrointestinal Conditions: If you have a history of gastrointestinal issues, such as gastritis, peptic ulcers, or other digestive disorders, serratiopeptidase may irritate your stomach lining and worsen your condition. Consult your doctor before use. 
• Liver Disease: Individuals with liver problems should be cautious when taking serratiopeptidase, as there is limited safety data for this group

Pregnancy / Lactation

Pregnancy consideration:  

pregnancy category: not assigned 

Lactation: excreted into human milk: unknown   

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• <b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

serratiopeptidase, an enzyme derived from the Serratia species of bacteria, is known for its anti-inflammatory, analgesic, and fibrinolytic properties. This enzyme works by breaking down and dissolving non-living tissue, including dead cells, blood clots, and fibrin deposits. It exerts its effects by inhibiting or modulating various proinflammatory molecules, such as bradykinin and prostaglandins, and by the release of anti-inflammatory substances.

serratiopeptidase is thought to reduce swelling and pain, making it a popular dietary supplement and over-the-counter medication for various conditions associated with inflammation. Its pharmacological action suggests potential benefits for conditions like arthritis, sinusitis, and post-surgical recovery, although research on its efficacy is ongoing.  

Pharmacodynamics: 

• Anti-Inflammatory Activity: serratiopeptidase reduces inflammation by breaking down inflammatory mediators like bradykinin and prostaglandins. This can lead to decrease in pain and swelling, making it useful in conditions associated with inflammation. 
• Fibrinolytic Activity: The enzyme can dissolve or break down fibrin, which is involved in blood clot formation. By doing so, it may help improve blood circulation and prevent excessive blood clotting in certain conditions. 
• Analgesic Properties: serratiopeptidase may have mild pain-relieving (analgesic) properties. It is often used in combination with other pain relief drugs to enhance their efficacy. 
• Reduced Viscosity: serratiopeptidase can reduce the viscosity of mucus and other secretions. This property is employed in medications for respiratory conditions to make mucus easier to clear. 
• Mucolytic Activity: The enzyme may help break down and thin mucus, making it easier to clear from the respiratory passages. This property is beneficial in conditions like chronic obstructive pulmonary disease (COPD) and sinusitis.

Pharmacokinetics: 

Absorption 

serratiopeptidase is usually administered orally in the form of tablets or capsules. It is absorbed through the gastrointestinal tract after oral administration. The absorption rate depends on factors such as the formulation and whether it is taken with or without food. 

Distribution 

Once absorbed, serratiopeptidase is distributed throughout the body. It can reach the sites of inflammation or injury where it exerts its anti-inflammatory and fibrinolytic effects. The enzyme’s distribution may vary depending on the condition being treated. 

Metabolism 

serratiopeptidase is not significantly metabolized in the body. It remains stable as it performs its enzymatic functions. 

Elimination and excretion 

The elimination of serratiopeptidase from the body primarily occurs through renal excretion. The kidneys filter the enzyme from the bloodstream, and it is then excreted in the urine. 

Adminstartion

Administration: 

• Dosage: The recommended dosage of serratiopeptidase can vary widely depending on the product and the medical condition it is intended to treat.  
• Administration Route: serratiopeptidase is taken by mouth with a full glass of water. It is usually administered on an empty stomach, typically 30 minutes before meals or 2 hours after meals, to enhance its absorption. 
• Frequency: The frequency of serratiopeptidase administration can also vary based on specific product and the condition. It is commonly taken one to three times a day. 
• Duration: The duration of treatment with serratiopeptidase will depend on the medical condition being treated. Follow your healthcare provider’s recommendations for how long you should take it. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: serratiopeptidase 

Pronounced: (suh-RAT-ee-oh-pep-tuh-days)  

Why do we use serratiopeptidase? 

serratiopeptidase is used to reduce inflammation in various conditions, such as arthritis, joint pain, and other inflammatory disorders. It helps by breaking down inflammatory byproducts and preventing the formation of excess fibrin, which can lead to tissue damage. This enzyme is often used as an analgesic to manage pain associated with inflammation, injuries, and postoperative recovery.

serratiopeptidase may be used to help improve symptoms in respiratory conditions like chronic obstructive pulmonary disease (COPD), sinusitis, and bronchitis. It can reduce mucus viscosity and ease breathing difficulties. In some cases, serratiopeptidase may be used to assist in wound healing by reducing inflammation and promoting the body’s natural repair processes. serratiopeptidase is employed in the treatment of sinusitis and other ENT conditions to reduce inflammation, facilitate mucus drainage, and alleviate symptoms.