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Brand Name :
Regiocit
Synonyms :
sodium chloride/sodium citrate
Class :
Anticoagulant
Brand Name :
Regiocit
Synonyms :
sodium chloride/sodium citrate
Class :
Anticoagulant
Dosage Forms & Strengths
Solution
(sodium 140 mEq/L, citrate 54 mEq/L, chloride 86 mEq/L)
The prefilter infusion rate is adjusted based on the blood flow rate in order to reach a desired blood citrate level of 3 to 4 mmol/L
The flow rate for anticoagulation of the extracorporeal circuit should be adjusted to achieve a post-filter ionized calcium level of 0.25 to 0.35 mmol/L
Dosing modification
Renal Impairment
Dose modification not required
Hepatic Impairment
Mild to moderate:
Observe for citrate accumulation
Severe impairment:
Stop using in patients with severe failure
Not determined
Refer to adult dosing
Actions and Spectrum
sodium chloride is an essential mineral required for the normal functioning of the human body. It plays a vital role in maintaining fluid balance, nerve function, and muscle contractions. sodium citrate is a salt of citric acid and sodium. It acts as a buffering agent and is used to control the acidity or pH of solutions.
Frequency not defined
Hypotension
Hypomagnesemia
Fluid volume disorder
Hypokalemia
Metabolic acidosis
Hypophosphatemia
Metabolic alkalosis
Hypoglycemia
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
sodium chloride ions are essential for nerve cell function and transmission of nerve impulses. They help generate action potentials necessary for communication between nerve cells and muscle cells.
sodium citrate can bind to certain metal ions. This chelating action can be useful in preventing the formation of kidney stones and as a component of anticoagulant solutions used in blood collection tubes.
Pharmacodynamics
sodium chloride ions are involved in the depolarization phase of action potentials in nerve cells and muscle fibers. This is fundamental for nerve conduction and muscle contraction.
sodium citrate acts as a buffer, helping to regulate the body’s acid-base balance. It can neutralize excess stomach acid and raise the pH of stomach contents.
Pharmacokinetics
Absorption
sodium chloride/sodium citrate both rapidly absorbed in the gastrointestinal tract.
Distribution
sodium chloride/sodium citrate both are distributed throughout the extracellular fluid compartments of the body.
Metabolism
sodium chloride is not metabolized in the body. It dissociates into sodium ions (Na+) and chloride ions (Cl-).
While sodium citrate is metabolized in the liver, where it is converted to bicarbonate ions.
Elimination and excretion
The excess amount of sodium ions and sodium citrate both excreted through the kidneys.
Administration
It should be use via extracorporeal administration only and avoid direct intravenous administration.
Administer using an integrated preblood pump with proper extracorporeal renal replacement equipment in predilution mode only.
Patient information leaflet
Generic Name: sodium chloride/sodium citrate
Why do we use sodium chloride/sodium citrate?
sodium chloride/sodium citrate is used as replacement solution in adults in treatment of continuous renal replacement therapy (CRRT).
sodium chloride is used to rehydrate patients and restore electrolyte balance, especially in case of dehydration.
sodium citrate is used as antacids to relieve heartburn, indigestion, and acid reflux by neutralizing excess stomach acid.
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