A Framework for Fitness-for-Purpose and Reuse in Computational Phenotyping
November 17, 2025
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Brand Name :
Avar LS, Cerisa Wash, Clarifying Wash, Rosula Wash, Avar-E, Avar LS, Avar-E LS, Clenia Foaming Wash
Synonyms :
sodium sulfacetamide/sulfur
Class :
Antiseborrheic agents, Topical Antipsoriatics, Topical Acne agents,Topical combos
Brand Name :
Avar LS, Cerisa Wash, Clarifying Wash, Rosula Wash, Avar-E, Avar LS, Avar-E LS, Clenia Foaming Wash
Synonyms :
sodium sulfacetamide/sulfur
Class :
Antiseborrheic agents, Topical Antipsoriatics, Topical Acne agents,Topical combos
Dosage forms and strengths Â
sodium sulfacetamide/sulfurÂ
topical creamÂ
10%/2%Â Â
10%/5%Â Â
topical cream with sunscreenÂ
10%/5%Â Â
topical foamÂ
10%/5%Â Â
CleanserÂ
10%/5%Â Â
10%/4.5%Â Â
10%/4%Â Â
10%/2%Â Â
10%/1%Â Â
9%/4.5%Â Â
9%/4%Â Â
8%/4%Â Â
Cleansing ClothÂ
10%/5%Â Â
Cream: Administer a thin layer of the cream as required, either once daily or up to three times daily
Foam: This should be done once a day or twice a day
If necessary, rinse off the foam after 1-2 minutes
Cleanser: Apply the cleanser to damp skin and gently massage it either once a day or twice a day
Afterward, rinse your skin thoroughly and pat it dry
Cleansing Pads: Take a wet pad and apply it to wet skin
Work the pad into a full lather, excluding the eye area, for 10-20 seconds
To cure potential dryness, it is advisable to commence with a single daily application and progressively recommend it to 2-3 times per day as deemed necessary
Cream: Administer the cream in a thin layer, with a frequency ranging from once daily to up to three times daily, based on individual needs
Foam: Cleanse the affected area thoroughly and massage the foam into it once daily to twice daily
If required, rinse off the foam after 1-2 minutes
Cleanser: Wet your skin and gently massage the cleanser onto it once daily to twice daily
Cleansing Pads: Take a wet pad and apply it to wet skin, working it into a rich lather for 10-20 seconds while avoiding the eye area
To minimize the possibility of dryness, begin with one application daily, then gradually increase to 2-3 times daily as needed
Dosage forms and strengthsÂ
sodium sulfacetamide/sulfurÂ
topical creamÂ
10%/5%Â Â
10%/2%Â Â
topical cream with sunscreenÂ
10%/5%Â Â
topical foamÂ
10%/5%Â Â
CleanseÂ
10%/5%Â Â
10%/4.5%Â Â
10%/4%Â Â
10%/2%Â Â
10%/1%Â Â
9%/4.5%Â Â
9%/4%Â Â
8%/4%Â
Cleansing ClothÂ
10%/5%Â Â
Cream: Administer a thin coat of the cream to the impacted regions once per day or as required, with the option to increase the frequency up to three times daily
Foam: Massage the foam gently into the affected area once a day or twice a day
If you need to remove the foam, rinse it off after 1-2 minutes
Cleanser: Apply the cleanser to wet skin and gently massage it into the skin once a day or twice a day
Rinse your skin thoroughly and pat it dry afterward
Cleansing Pads: Take a wet pad and apply it to wet skin
Work the pad into a full lather for 10-20 seconds, making sure to avoid the eye area
Rinse your skin thoroughly and pat it dry
Dispose of the used pad properly
To minimize the potential dryness
It is advised to initiate with a single utilization per day and progressively escalate it to 2-3 instances on a daily basis, as deemed necessary
Refer adult dosingÂ
Actions and SpectrumÂ
Action:Â Â
It possesses both antibacterial and antifungal properties. The action of sodium sulfacetamide is primarily antibacterial, as it inhibits the growth of certain bacteria on the skin. Â
The combination of sodium sulfacetamide and sulfur provides a synergistic effect in treating conditions such as acne, rosacea, seborrheic dermatitis, and dandruff. sodium sulfacetamide targets the bacteria associated with these skin conditions, while sulfur helps to reduce inflammation and excess oil production.Â
Spectrum:Â Â
The spectrum of activity of sodium sulfacetamide/sulfur primarily covers bacteria and fungi commonly found on the skin. It is effective against various gram-positive and gram-negative bacteria, including Propionibacterium acnes, Staphylococcus epidermidis, and some Streptococcus species. These bacteria are often associated with acne and other inflammatory skin conditions.Â
Frequency not defined Â
EdemaÂ
Local irritationÂ
ErythemaÂ
ItchingÂ
PruritusÂ
Black Box Warning:Â Â
None Â
Contraindication/Caution:Â Â
Hypersensitivity or allergy: Individuals who have known hypersensitivity or allergic reactions to sodium sulfacetamide, sulfur, or any other ingredients in the formulation should avoid using this medication.Â
Asthma: The drug may trigger asthma attacks or worsen existing asthma symptoms in some individuals. Â
G6PD deficiency: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited condition that affects red blood cells. Some studies suggest that sulfacetamide may cause hemolysis (breakdown of red blood cells) in individuals with G6PD deficiency. Therefore, caution is advised in such cases.Â
Pregnancy and breastfeeding: The safety of sodium sulfacetamide/sulfur during pregnancy and breastfeeding has not been well-established.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:Â Â
sodium sulfacetamide/sulfur is a combination medication used in dermatology for the treatment of various skin conditions, including acne, rosacea, seborrheic dermatitis, and dandruff. It is available in topical formulations such as creams, gels, and cleansers.Â
Pharmacodynamics:Â Â
sodium Sulfacetamide:Â
 sodium sulfacetamide is a sulfonamide antibiotic. It works by inhibiting the growth of bacteria on the skin, particularly those associated with acne, such as Propionibacterium acnes. It acts by interfering with bacterial folate synthesis, an essential process for the production of DNA and proteins in bacteria.Â
Anti-inflammatory Effects: In addition to its antimicrobial action, sodium sulfacetamide also has anti-inflammatory properties.Â
sulfur:Â
sulfur has keratolytic and antimicrobial properties. It works by promoting the shedding of dead skin cells and unclogging pores.Â
Keratolytic Effects: sulfur helps to break down and remove the outer layer of the skin (stratum corneum) by increasing its hydration and reducing the adhesion between skin cells. This promotes exfoliation and helps to unclog pores.Â
Antimicrobial Effects: sulfur has a broad-spectrum antimicrobial activity against certain bacteria and fungi.  Â
Pharmacokinetics:Â
AbsorptionÂ
The drug can be administered topically in the form of creams, gels, or lotions. When applied to the skin, the medication is primarily absorbed locally into the skin layers. Systemic absorption is generally minimal, but small amounts may enter the bloodstream.Â
DistributionÂ
 sodium sulfacetamide/sulfur may be distributed within the skin and underlying tissues. There is limited information available regarding its distribution beyond the skin.Â
MetabolismÂ
The drug undergoes minimal metabolism. Sodium sulfacetamide is primarily metabolized in the liver via acetylation and hydrolysis processes. sulfur does not undergo significant metabolism.Â
Excretion and eliminationÂ
Both sodium sulfacetamide and sulfur are eliminated primarily through the kidneys. They are excreted in the urine as unchanged drug or metabolites.Â
Administration: Â
Prepare the affected area: Prior to administering the medication, cleanse the affected region using a mild cleanser, ensuring it is thoroughly rinsed and dried.Â
Apply a thin layer: Utilize a sanitized finger or applicator to gently spread a thin layer of the medication onto the affected skin. Massage it in gently until absorption occurs. Â
Application frequency: Generally, it is applied once or twice daily. Adhere to the recommended frequency and avoid exceeding the prescribed dosage.Â
Maintain consistency: It is crucial to consistently use sodium sulfacetamide/sulfur as directed by your healthcare provider. Acne treatments require time to take effect, so adhere to the recommended regimen on a regular basis.Â
Patient information leafletÂ
Generic Name: sodium sulfacetamide/sulfurÂ
Why do we use sodium sulfacetamide/sulfur?  Â
Acne: sodium sulfacetamide/sulfur is frequently prescribed for acne vulgaris, a common skin condition characterized by the formation of pimples, blackheads, and whiteheads. Â
Rosacea: sodium sulfacetamide/sulfur can help alleviate the symptoms of rosacea by reducing inflammation and minimizing the occurrence of pustules.Â
Seborrheic dermatitis: skin condition that causes red, itchy, and flaky patches on the scalp, face, and other areas with sebaceous glands. sodium sulfacetamide/sulfur can be used to manage Â
Dandruff: The combination of sodium sulfacetamide and sulfur can help combat dandruff, a condition characterized by flaky scalp skin. It works by reducing the overgrowth of yeast on the scalp and controlling the associated inflammation.Â
Folliculitis: This is hair follicles infection which can lead to red, itchy bumps or pustules. sodium sulfacetamide/sulfur can be used to treat folliculitis by controlling the bacterial overgrowth and reducing inflammation.Â
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