sofnobrutinib

Action and Spectrum

Actions and Spectrum: 

The action of the drug involves inhibiting the enzyme Bruton’s tyrosine kinase activity, hence which is helpful in the activation and proliferation inhibition. 

Drug Interaction

Adverse Reaction

None

Black Box Warning

None

Contraindication / Caution

Contraindication/Caution: 

Individuals with following situations should use the drug cautiously: 

Hypersensitivity  

Active bleeding 

Severe liver or kidney impairment 

Pregnancy / Lactation

Pregnancy Warnings:  

Pregnancy category: N/A  

Lactation:  

Excretion of the drug in human breast milk is unknown  

Pregnancy Categories:    

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.    

<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.    

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.    

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.    

Category N: There is no data available for the drug under this category.

Pharmacology

Pharmacology:  

Sofnobrutinib is a bruton’s tyrosine kinase inhibitor (BTK inhibitor). It selectively binds and inhibits the activity of BTK.  

Pharmacodynamics:  

Sofnobrutinib interferes with BTK signaling and leads to the suppression of abnormal B-cell activity.  

Pharmacokinetics:  

Limited information available for ADME. 

Adminstartion

Administration:

The route of administration is not fully known. 

Patient Information Leaflet

Patient information leaflet: 

Generic Name: sofnobrutinib 

Why do we use sofnobrutinib? 

Sofnobrutinib is used as an investigation drug which is indicated for various B-cell malignancies like lymphomas and leukemias.