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January 1, 2026
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Brand Name :
Arlex
Synonyms :
sorbitol
Class :
Osmotic, Laxative
Brand Name :
Arlex
Synonyms :
sorbitol
Class :
Osmotic, Laxative
Dosage Forms & Strengths
Irrigation solution
3g/100ml
Oral solution
70%
Take dose of 30 to 150 ml orally one time
Rectal enema: Inject 120 ml of 25 to 30% solution one time
Dosage Forms & Strengths
Irrigation solution
3g/100ml
Oral solution
70%
Safety and efficacy not determined in less than two years old
2 to 11 years:
Take 2 ml/kg orally one time
Rectal enema: inject 30 to 60 ml as 25 to 30% solution
≥12 years:
Take dose of 30 to 150 ml orally one time
Rectal enema: inject 120 ml of 25 to 30% solution one time
Refer to adult dosing
sorbitol: they may diminish the serum concentration of lamivudine
sorbitol: they may increase the toxic effect of calcium polystyrene sulfonate
sorbitol: they may increase the toxic effect of sodium polystyrene sulfonate
when used with ipratropium, sorbitol's therapeutic efficacy may be diminished
Actions and Spectrum
sorbitol is approximately 60% as sweet as sucrose. Various products, including sugar-free candies, chewing gum, beverages, and baked goods, use it to add sweetness.
sorbitol has hygroscopic properties, which means it can draw in and hold moisture. As a bulking agent, sorbitol can give food products more volume and texture.
IR spectroscopy measures the absorption of infrared radiation by the sample, providing information about its functional groups and molecular structure.
Frequency not defined
Edema
Abdominal discomfort
Xerostomia
Dehydration
Dry mouth
Vomiting
Nausea
Fluid and electrolyte losses
Lactic acidosis
Diarrhea
Hyperglycemia
Excessive bowel activity
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy warnings:
Pregnancy category: C
Lactation: Advise to use cautiously as excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
sorbitol has pharmacological properties that are primarily focused on its use as a humectant and sweetener.
sorbitol also has osmotic properties that have the potential to have laxative effects. This higher water content encourages bowel movements.
Pharmacodynamics
sorbitol works as an osmotic agent in the colon, drawing water through osmosis into the intestinal lumen to raise the water content of the bowel.
The osmotic impact softens the stool and encourages bowel movement, making sorbitol beneficial as an osmotic laxative for treating constipation.
Pharmacokinetics
Absorption
Through passive diffusion, sorbitol is absorbed in the small intestine. It is not completely absorbed and reaches the colon.
Distribution
sorbitol is distributed throughout the body’s water compartments. It can draw water into the colon as a result of its osmotic properties, increasing the water content of the intestinal lumen.
Metabolism
The body uses the enzyme sorbitol dehydrogenase to convert sorbitol to fructose. Through typical metabolic pathways for carbohydrates, fructose is further processed.
Elimination and excretion
sorbitol and its metabolite, fructose, are primarily excreted in the urine.
Administration
sorbitol can be administered orally and is commonly available in various forms for consumption.
Patient information leaflet
Generic Name: sorbitol
Why do we use sorbitol?
In a variety of food and beverage products, sorbitol is frequently used as a sugar substitute and sweetening agent.
A humectant and sweetener, sorbitol is utilised in medicinal compositions.
As an osmotic laxative, sorbitol has medical uses. It softens the feces and draws water into the intestines to treat constipation.
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