Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
N/A
Synonyms :
Aiguillat, Spiny Dogfish Shark, Escualamina, Squalene, Squalus acanthias
Class :
antibiotic
Brand Name :
N/A
Synonyms :
Aiguillat, Spiny Dogfish Shark, Escualamina, Squalene, Squalus acanthias
Class :
antibiotic
Dosage forms and strengths
tablet
0.5 g/L
not indicated
refer adult dosing
may enhance the adverse/toxic effect of bisphosphonate derivatives
may enhance the adverse/toxic effect of bisphosphonate derivatives
may enhance the adverse/toxic effect of bisphosphonate derivatives
may enhance the adverse/toxic effect of bisphosphonate derivatives
may enhance the risk of adverse effect of bisphosphonate derivatives
may enhance the risk of adverse effect of bisphosphonate derivatives
may enhance the risk of adverse effect of bisphosphonate derivatives
may enhance the risk of adverse effect of bisphosphonate derivatives
may increase the risk of adverse effects
Actions and Spectrum:
squalamine is a compound found in the tissues of certain shark species and has been investigated for its potential pharmacological actions. It has primarily been studied for its antimicrobial, antiangiogenic (inhibiting blood vessel formation), and potential anti-cancer properties.
Antimicrobial: squalamine has shown promise as an antimicrobial agent. It has demonstrated activity against a wide range of pathogens, including bacteria, viruses, and fungi. This antimicrobial property makes it a potential candidate for the development of new antibiotics or antiviral drugs.
Antiangiogenic: One of the notable actions of squalamine is its ability to inhibit angiogenesis, which is the process of forming new blood vessels. This property has led to research into its potential use in inhibiting the growth of blood vessels associated with diseases like cancer and certain eye conditions, such as age-related macular degeneration.
Anti-Cancer: Squalamine’s antiangiogenic properties have also raised interest in its potential as an anti-cancer agent. By inhibiting the formation of new blood vessels, it may help limit the blood supply to tumors, potentially slowing their growth. However, its efficacy and safety for cancer treatment are still being studied.
Frequency not defined
nausea
vomiting
decreased appetite
muscle cramps
None
Contraindication / Caution:
squalamine is considered potentially safe for adults when administered as eye drops for up to 38 weeks or when given intravenously under the supervision of a healthcare professional. However, intravenous injections of squalamine may lead to adverse effects such as nausea, vomiting, decreased appetite, muscle cramps, or fatigue.
The safety of oral consumption of squalamine and its potential side effects remain unknown. Regarding pregnancy and breastfeeding, there is insufficient information available about the use of squalamine during these periods. It is advisable to err on the side of caution and avoid its use.
For children aged 6-15 years, applying squalamine topically to the skin for a short duration is considered potentially safe.
Pregnancy warnings:Â Â Â
Pregnancy category: N/A
Lactation:Â Excreted into human milk is unknown
Pregnancy Categories:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
limited information available
Patient information leaflet
Generic Name: squalamine
Why do we use squalamine?
squalamine is a compound found in the tissues of certain shark species and has been studied for various potential medical applications. It has demonstrated antimicrobial properties in laboratory studies. It has shown effectiveness against a wide range of pathogens, including bacteria, viruses, and fungi. This antimicrobial activity raises the possibility of developing new treatments for infectious diseases.
squalamine has been investigated for its ability to inhibit angiogenesis, the process of forming new blood vessels. This property is of interest in conditions where excessive blood vessel growth plays a role, such as certain types of cancer and eye diseases like age-related macular degeneration.
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