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January 1, 2026
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Brand Name :
Quelicin
,Anectine
Synonyms :
succinylcholine
Class :
Neuromuscular Blockers, Depolarizing
Brand Name :
Quelicin
,Anectine
Synonyms :
succinylcholine
Class :
Neuromuscular Blockers, Depolarizing
Dosage Forms & Strengths
Injectable solution
20mg/ml
100mg/ml
Dosage Forms & Strengths
Injectable solution
20mg/ml
100mg/ml
Action and spectrum:
Suxamethonium also known as succinylcholine, is a depolarizing neuromuscular blocking agent. It acts as an agonist at the nicotinic acetylcholine receptor at the neuromuscular junction which causes rapid and short-lived depolarization of the muscle fiber.
Adverse drug reactions:
Frequency Not Defined
Respiratory depression
Jaw rigidity
Apnea
Salivary gland enlargement
Excessive salivation
Rash
Hypersensitivity reactions
Malignant hyperthermia
Bradycardia
Hypotension
Cardiac arrhythmias
Sinus tachycardia
Black box warning
Suxamethonium can cause malignant hyperthermia.
The drug is used only in emergency situations, for e.g., during intubation or electroconvulsive therapy.
Contraindication/Caution:
Contraindication:
Hypersensitivity
Hyperkalemia
Renal failure
Caution:
Acute narrow-angle glaucoma
Prolonged immobilization or bed rest
Liver disease
Pregnancy warnings:
US FDA pregnancy category: unassigned
Breastfeeding warnings:
The release of the drug into the human breastmilk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
It initially stimulates the nicotinic acetylcholine receptors which causes depolarization of the muscle cell membrane and muscle contraction.
Pharmacodynamic
The action of acetylcholine produces a depolarizing muscle relaxation by opening the ion channels which allows the influx of sodium ions.
Pharmacokinetics:
Absorption
It is rapidly absorbed into the bloodstream.
Distribution
It is distributed throughout the body.
Metabolism
It is metabolized by plasma cholinesterase.
Elimination and excretion
It is excreted in the urine.
Administration:
It is administered intravenously i.e., deep into the vein.
Patient Information Leaflet
Generic Name: succinylcholine
Why do we use succinylcholine?
succinylcholine is an Neuromuscular Blocking Agents which is used for Skeletal Muscle Relaxation
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