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Brand Name :
Sucral-O, Macralfate-O, Sucraday O
Synonyms :
sucralfate/oxethazaine
Class :
Pepsin inhibitor and antiulcer agents
Brand Name :
Sucral-O, Macralfate-O, Sucraday O
Synonyms :
sucralfate/oxethazaine
Class :
Pepsin inhibitor and antiulcer agents
Dosage Forms & Strengths
Emulsion
100 ml
200 ml
Take a dose orally as per physician advised
Not determined
Refer to adult dosing
Actions and Spectrum
sucralfate is an aluminium salt of sucrose sulfate. It works by forming a protective barrier or coating on the mucosal lining of the stomach and duodenum.
This protective barrier acts as a physical barrier against stomach acid, pepsin, and other irritants, promoting the healing of ulcers and reducing irritation in the gastrointestinal tract.
oxethazaine is a local anaesthetic and antacid combination. It contains an anaesthetic (oxethazaine) and an antacid (aluminum hydroxide) to provide relief from pain and discomfort associated with various gastrointestinal conditions.
Frequency not defined
Constipation
Dizziness
Insomnia
Nausea
Vomiting
Allergic reaction
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
When taken orally, sucralfate forms a thick, viscous, and adhesive gel-like substance in the stomach. This gel adheres to the damaged mucosal lining of the stomach and duodenum, creating a protective barrier against gastric acid, pepsin, and other irritants.
oxethazaine is a local anesthetic that is often combined with antacids for gastrointestinal symptom relief. Its primary action is to provide temporary relief from pain, burning sensations, or discomfort associated with various gastrointestinal conditions like gastritis, esophagitis, and peptic ulcers.
Pharmacodynamics
sucralfate primarily acts by creating a protective barrier on the mucosal lining of the stomach and duodenum. This barrier adheres to the damaged or ulcerated areas, forming a physical shield against gastric acid, pepsin, and other irritants. It also stimulates the secretion of mucus and bicarbonate in the gastric mucosa, which enhances the protective effect.
oxethazaine is a local anesthetic that works by blocking the transmission of pain signals in nerves. By numbing the area and reducing the sense of pain, oxethazaine helps to alleviate the burning or discomfort associated with various gastrointestinal conditions like gastritis, esophagitis, and peptic ulcers.
Pharmacokinetics
Limited information available on ADME.
Administration
sucralfate/oxethazaine is a combination drug available in emulsion form for oral intake.
Patient information leaflet
Generic Name: sucralfate/oxethazaine
Why do we use sucralfate/oxethazaine?
Sucral-O (sucralfate/oxethazaine) is a combination drug used to treat ulcers. It also covers the damaged ulcer tissue in the stomach and protects it from acid. It is used in the treatment of acidity and heartburns.
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