Fame and Mortality: Evidence from a Retrospective Analysis of Singers
November 26, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Journavx
Synonyms :
Suzetrigine
Class :
NaV Inhibitors
Brand Name :
Journavx
Synonyms :
Suzetrigine
Class :
NaV Inhibitors
Tablet
50 mg
Safety and efficacy not determined
Refer as per adult dose
It works as a selective inhibitor of the sodium channels are involved in transmitting pain signals.
Suzetrigine blocks pain signals to the brain, that gives non-addictive effective pain relief.
Suzetrigine offers comparable pain relief with fewer side effects than opioids.
NaV1.8 in sensory neurons transmits pain signals via dorsal root ganglion neurons.
Frequency defined:
>10%
Vomiting
Nausea
1-10%
Muscle spasms
Pruritus
Increased blood creatine phosphokinase
Rash
None
Coadministration with strong CYP3A inhibitors
Caution:
Hepatic impairment (Moderate and Severe)
Drug interaction
Hormonal contraceptives
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Suzetrigine selectively blocks NaV1.8 sodium channels in peripheral nociceptive neurons including dorsal root ganglion neurons transmit nociceptive signals.
It selectively blocks pain signal transmission to brain. M6-SUZ is 3.7-fold less potent than suzetrigine to inhibit NaV1.8.
Pharmacodynamics
Suzetrigine reduces addiction risk without affecting opioids.
Comparable analgesia to opioids without respiratory depression.
The duration of analgesic effect based on quantity of dose to provides sustained pain relief.
Pharmacokinetics
Absorption:
Peak plasma levels are reached within 3 hours after oral intake.
Area of curve for 0 to 24 hours duration is 11.5 mcgâ‹…h/ml.
Distribution:
Volume of distribution: 495 L
It has high protein binding up to 99%.
Metabolism:
Parent and active metabolite metabolized through CYP3A pathways.
Elimination and excretion:
It is excreted though urine and feces route.
Half-life shows up to 23.6 hours while clearance of 13.9 L/hr.
It is available in tablet form for oral administration.
Swallow whole tablet with water and do not crush or chew the tablet.
Take dose on an empty stomach 1 hour before or 2 hours after food.
Take missed dose promptly and then continue with schedule.
Generic Name: Â suzetrigine
Why do we use suzetrigine?
Suzetrigine is indicated in the treatment of acute pain.
It is used in postoperative pain to manage pain after surgeries.
It provides pain relief without the risk of addiction and sedation.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
