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Brand Name :
Bonalfa
Synonyms :
tacalcitol
Class :
Gastrointestinal agent, Vitamin D derivatives, Activated vitamin D3, Antipsoriatic, Vitamin D receptor agonist
Dosage Forms & Strengths
Ointment and cream
0.1%
0.05%
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
the risk or intensity of unfavorable effects can be heightened when tacalcitol is coupled with calcium acetate
the risk or gravity of adverse effects can be elevated when tacalcitol is linked with calcium carbonate
the risk or magnitude of adverse effects can be heightened when tacalcitol is connected with calcium chloride
the risk or extent of adverse effects can be heightened when tacalcitol is associated with calcium citrate
anhydrous the risk or magnitude of adverse effects can be heightened when tacalcitol is correlated with calcium glubionate anhydrous
the risk or intensity of unfavorable effects can be heightened when tacalcitol is linked with calcium polycarbophil
the serum concentration of tacalcitol can be lessened when it is associated with fosphenytoin
the serum concentration of tacalcitol can be reduced when it is linked with phenytoin
the risk or intensity of unfavorable effects can be heightened when tacalcitol is correlated with calcium glucoheptonate
the risk or magnitude of adverse effects can be elevated when tacalcitol is associated with calcium gluconate
the risk or extent of adverse effects can be heightened when tacalcitol is linked with calcium lactate
the risk or magnitude of adverse effects can be heightened when tacalcitol is correlated with calcium levulinate
the risk or extent of adverse effects can be heightened when tacalcitol is associated with calcium phosphate
Actions and Spectrum:
Actions:
Tacalcitol affects skin cells’ growth rate and maturation process. It prevents excessive cellular multiplication – an issue central to psoriasis pathology. Additionally, tacalcitol modulates skin inflammation; a characteristic feature of this dermatological condition. Consequently, it exhibits therapeutic efficacy against various psoriatic subtypes, including plaque psoriasis.
Spectrum:
Tacalcitol comes as an ointment, similar to vitamin D. Applied twice daily in Japan, but once per day in Western countries. It helps manage psoriasis by calming irritated skin. Tacalcitol has minimal absorption into the body. Research shows it is effective, with few adverse effects even after prolonged use over a couple of months. However, some individuals may experience mild skin irritation when using this medication.
Frequency not defined
Parestheia
Contact dermatitis
Itching
Erythema
Hypercalcemia
Skin irritation
Burning
Black Box Warning:
To use tacalcitol safely, avoid putting it on open sores or wet parts of your body. Be extra careful around eyes. Watch out for high calcium levels, especially if using long-term or if at risk. People with calcium issues need special care with tacalcitol. Don’t let it touch tender areas. Monitor closely for side effects related to calcium. Proper precautions are vital to prevent complications when using this medication.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Tacalcitol works by connecting with receptors for vitamin D found on keratinocytes. These are skin cells. Tacalcitol helps control the replacement of cells. These are cells in the outer layer of skin.
Pharmacodynamics:
Tacalcitol works by stopping too many skin cells from growing. It comes from vitamin D3. Tacalcitol binds to vitamin D receptors. This causes skin cells to grow normally again. So it helps treat psoriasis. Psoriasis is a disease where skin cells grow too fast. Tacalcitol stops this excessive growth of skin cells. It lets skin cells grow at a regular pace instead. That’s how this medicine improves psoriasis symptoms.
Pharmacokinetics:
Absorption
Tacalcitol is a medicine for skin conditions like psoriasis. When applied to affected areas, a tiny amount (0.5%) gets absorbed by the body.
Distribution
It completely binds to proteins in the blood as it travels through the body.
Elimination and Excretion
Elimination of Tacalcitol happens mainly through urine.
Administration:
Tacalcitol comes in creams or ointments to put on the skin. First, wash the affected areas. Next, apply a thin layer of the medicine. Use it as often as prescribed. It’s important to apply only where needed and avoid healthy skin. Your doctor will say how long to use tacalcitol based on your progress. You’ll have regular check-ups to see how it’s working and address any issues that come up.
Patient information leaflet
Generic Name: tacalcitol
Pronounced: tuh-KAL-si-tol
Why do we use tacalcitol?
Tacalcitol, a vitamin D3 look-alike, helps treat skin troubles. It works on psoriasis—scaly, red, and itchy patches from fast-growing skin cells. Tacalcitol attaches to vitamin D receptors in skin. This controls cell growth and immune responses. Its anti-inflammatory and anti-cell-growth traits reduce redness, scaling, and itching with psoriasis.
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