A Framework for Fitness-for-Purpose and Reuse in Computational Phenotyping
November 17, 2025
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Brand Name :
Cognex
Synonyms :
tacrine
Class :
Cholinesterase inhibitors
Brand Name :
Cognex
Synonyms :
tacrine
Class :
Cholinesterase inhibitors
Dosage Forms & Strengths
Capsule
10 mg
20 mg
30 mg
40 mg
Take an initial dose of 10 mg orally four times daily if possible, in between food up to 6 weeks
The maintenance dose may raise up to 20 mg orally four times daily
It may further raise up to 120 mg and 160 mg daily may be done in 6-week intervals
Not determined
Refer to adult dosing
when bromazepam and tacrine are used together, there is a potential reduction in the bromazepam's metabolism
When tacrine is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Actions and Spectrum
tacrine belongs to a class of drugs called acetylcholinesterase inhibitors (AChE inhibitors). Acetylcholinesterase is an enzyme that breaks down acetylcholine, a neurotransmitter in the brain that is essential for memory and cognitive function. tacrine works by inhibiting acetylcholinesterase, which increases the levels of acetylcholine in the brain.
Frequency not defined
Ataxia
Vomiting
Diarrhea
Headache
Dizziness
Nausea
Myalgia
Hepatotoxicity
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: C
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
tacrine’s inhibition of acetylcholinesterase helps to alleviate the cholinergic deficit by increasing the availability of acetylcholine in the synaptic cleft, which can improve cholinergic neurotransmission and cognitive function.
The cholinergic system is a major neurotransmitter system in the brain, and it plays a major role in cognitive processes.
Pharmacodynamics
tacrine slows down the breakdown of acetylcholine, leading to an increase in the concentration of acetylcholine in the synaptic gaps between neurons.
The cholinergic system is a major neurotransmitter system in the brain, and acetylcholine is a key neurotransmitter involved in cognitive functions.
Pharmacokinetics
Absorption
tacrine is rapidly absorbed from the gastrointestinal tract after oral administration.
Distribution
tacrine is distributed throughout the body, including the central nervous system (CNS).
Metabolism
tacrine undergoes extensive metabolism in the liver through the cytochrome P450 enzyme system.
Elimination and excretion
tacrine is primarily excreted in the urine. The Elimination half-life is approximately 2 to 4 hours.
Administration
tacrine is administered orally in the form of tablets or capsules.
Patient information leaflet
Generic Name: tacrine
Why do we use tacrine?
tacrine was used for the treatment of mild to moderate Alzheimer’s disease. tacrine increases the availability of acetylcholine in the brain, which can help improve cholinergic neurotransmission and alleviate some of the cognitive symptoms associated with Alzheimer’s disease.
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