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tafamidis

Brand Name :

Vyndamax, Vyndaqel

Synonyms :

tafamidis

Class :

Cardiovascular agent





No data available for drug.

Actions and Spectrum: 

  • tafamidis is a medication used to treat transthyretin-mediated amyloidosis (ATTR), a rare disease caused by the buildup of misfolded transthyretin protein in various tissues, including the heart and nerves. 
  • The mechanism of action of tafamidis is to stabilize the tetrameric structure of transthyretin, which prevents its misfolding and aggregation into amyloid fibrils. By stabilizing the tetramer, tafamidis reduces the amount of misfolded transthyretin available to form tissue amyloid deposits. 
  • The spectrum of activity of tafamidis is limited to ATTR, specifically to ATTR with polyneuropathy. It has been shown to slow the progression of neurological impairment in patients with early-stage ATTR polyneuropathy. tafamidis is ineffective in treating other types of amyloidosis or neuropathy. 

DRUG INTERACTION

tafamidis

&

  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
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  • carbazochrome
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  • cathine
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  • sermorelin
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  • calamine
  • canrenone
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  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
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  • mequinol/gluconolactone/ lactobionic acid/ arbutin
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  • micronomicin
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  • guaiacol glycerol ether
  • eucalyptol
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  • iceland moss
  • glutethimide
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  • dexpanthenol topical
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  • diazolidinylurea
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  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
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  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
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  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
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  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
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  • aluminum chloride (dental)
  • alum irrigation
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  • olipudase alfa
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  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel oral/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab-alip
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
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  • aducanumab
  • oxycodone/naloxone
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  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
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  • clocortolone
  • formaldehyde topical
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  • collagenase
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  • foscarbidopa/foslevodopa (FDA approval pending)
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  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • elamipretide (Pending FDA approval)
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene (FDA Approval Pending)
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic (FDA Approval Pending)
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab (FDA approval pending)
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • tepotinib 
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitinib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/metformin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
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tafamidis + 

alpelisib 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

berotralstat 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

cladribine 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

rosuvastatin 

may increase the myopathic effect of tafamidis

pazopanib 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

topotecan 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

lenacapavir

may enhance the serum concentration of tafamidis

abiraterone

may enhance the serum concentration of tafamidis

mibefradil

may enhance the serum concentration of tafamidis

isoniazid

may enhance the serum concentration of tafamidis

mexiletine

may enhance the serum concentration of tafamidis

imatinib 

may enhance the serum concentration of tafamidis

methotrexate 

may enhance the serum concentration of tafamidis

talazoparib 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

methotrexate

may increase the serum concentration of methotrexate

trimetrexate

may increase the serum concentration of trimetrexate

daunorubicin

increases the effects of daunorubicin by inhibiting BCRP transport

idarubicin

increases the effects of idarubicin by inhibiting BCRP transport

Contraindications/caution: 

Contraindications: 

None 

Caution: 

  • Liver function: tafamidis is primarily metabolized by the liver, so caution is advised in patients with liver dysfunction. Patients with moderate to severe hepatic impairment should be monitored closely for adverse effects. 
  • Pregnancy and breastfeeding: There is limited data on the safety of tafamidis use during pregnancy and breastfeeding, so caution should be exercised. 
  • Drug interactions: tafamidis is not known to interact with other medications. However, caution should be used when combined with drugs primarily metabolized by the liver or that may have hepatotoxic effects. 
  • Allergic reactions: Allergic reactions, including anaphylaxis, have been reported in patients taking tafamidis. Patients who develop signs of an allergic reaction should discontinue the medication and seek medical attention. 
  • Immunogenicity: There is a potential for patients to develop antibodies against tafamidis, which may reduce its effectiveness. Patients should be monitored for signs of decreased efficacy and the potential need for dose adjustments. 
  • Geriatric patients: While there are no specific cautions, they may be more likely to experience adverse effects due to age-related changes in drug metabolism and elimination. 

Pregnancy consideration: Insufficient data available 

Lactation: Excretion of the drug in human breast milk is unknown 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology:

tafamidis is a small molecule that selectively binds to transthyretin (TTR), a protein that plays a role in the transport of thyroid hormones and retinol-binding protein. In patients with TTR-mediated amyloidosis, mutations in the TTR gene can lead to unstable TTR tetramers, which can dissociate and form amyloid fibrils that accumulate in various tissues.

tafamidis binds to the thyroxine-binding sites of TTR, stabilizing the tetrameric structure of the protein and preventing its dissociation into monomers, which is a critical step in the formation of amyloid fibrils. By stabilizing the tetrameric structure, tafamidis reduces the misfolded TTR available to form tissue amyloid deposits.

Pharmacodynamics:

The pharmacodynamics of tafamidis is related to its mechanism of action, which is to stabilize the tetrameric structure of transthyretin (TTR) and prevent its dissociation into monomers. By doing so, tafamidis reduces the amount of misfolded TTR available to form amyloid fibrils, which can accumulate in various tissues and cause organ damage.

tafamidis has been shown to stabilize TTR tetramers in vitro and in vivo and reduce the dissociation rate of tetramers into monomers. In clinical studies, tafamidis has been shown to slow the progression of neuropathy in patients with TTR-mediated amyloidosis, with reductions in nerve impairment scores observed compared to placebo.

Pharmacokinetics:

Absorption

tafamidis is well-absorbed orally, and the peak plasma concentration is achieved 4 hours after administration. There are no clinically significant differences in the steady-state peak plasma concentration and AUC between the 61-mg capsule and the four 20-mg tafamidis meglumine capsules.

Distribution

tafamidis has a Vd (steady-state) of 18.5 L, indicating that it is widely distributed throughout the body. Over 99% of tafamidis is bound to plasma proteins, primarily to TTR.

Metabolism

The metabolism of tafamidis is not fully characterized, but it is known to undergo glucuronidation, a process by which glucuronic acid is added to the drug molecule, making it more water-soluble and easier to eliminate from the body.

Elimination and Excretion

tafamidis has a half-life of approximately 49 hours and an oral clearance of 0.263 L/hr. It is primarily eliminated through the feces, with about 59% of the drug being excreted unchanged in the feces. About 22% of the drug is eliminated in the urine, mainly as a glucuronide conjugate.

Administration:

Oral administration:

  • It may be consumed either with or without food
  • Swallow the pill whole; do not crush or cut it.
  • If a dosage is missed, either give it as soon as possible or skip it and take the following dose at the usually scheduled time; do not double the dose.

Storage:

Keep at room temperature (20-25°C [68-77°F]); excursions to 15-30°C (59-86°F) are acceptable.

Patient information leaflet

Generic Name: tafamidis

Why do we use tafamidis?

tafamidis is a medication used to treat a rare genetic disorder called transthyretin amyloidosis (ATTR), characterized by the buildup of abnormal proteins called amyloids in various tissues and organs throughout the body.

  • tafamidis is specifically approved for treating ATTR with cardiomyopathy, a disease that affects the heart.
  • tafamidis works by stabilizing the tetrameric structure of the transthyretin protein, which is the protein misfolded in ATTR. By stabilizing the protein, tafamidis helps to prevent the formation of amyloids and the subsequent damage to tissues and organs

ADVERTISEMENT 

tafamidis

Brand Name :

Vyndamax, Vyndaqel

Synonyms :

tafamidis

Class :

Cardiovascular agent




No data available for drug.

Dosage Forms & Strengths 

Capsule 

61mg 

Safety and efficacy not established 

Refer adult dosing 

DRUG INTERACTION

tafamidis

&

  • tolperisone
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  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel oral/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab-alip
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • elamipretide (Pending FDA approval)
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene (FDA Approval Pending)
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic (FDA Approval Pending)
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab (FDA approval pending)
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • tepotinib 
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitinib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/metformin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate sodium injection
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
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tafamidis + 

alpelisib 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

berotralstat 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

cladribine 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

rosuvastatin 

may increase the myopathic effect of tafamidis

pazopanib 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

topotecan 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

lenacapavir

may enhance the serum concentration of tafamidis

abiraterone

may enhance the serum concentration of tafamidis

mibefradil

may enhance the serum concentration of tafamidis

isoniazid

may enhance the serum concentration of tafamidis

mexiletine

may enhance the serum concentration of tafamidis

imatinib 

may enhance the serum concentration of tafamidis

methotrexate 

may enhance the serum concentration of tafamidis

talazoparib 

may enhance the serum concentration of BCRP/ABCG2 inhibitors

methotrexate

may increase the serum concentration of methotrexate

trimetrexate

may increase the serum concentration of trimetrexate

daunorubicin

increases the effects of daunorubicin by inhibiting BCRP transport

idarubicin

increases the effects of idarubicin by inhibiting BCRP transport

Actions and Spectrum: 

  • tafamidis is a medication used to treat transthyretin-mediated amyloidosis (ATTR), a rare disease caused by the buildup of misfolded transthyretin protein in various tissues, including the heart and nerves. 
  • The mechanism of action of tafamidis is to stabilize the tetrameric structure of transthyretin, which prevents its misfolding and aggregation into amyloid fibrils. By stabilizing the tetramer, tafamidis reduces the amount of misfolded transthyretin available to form tissue amyloid deposits. 
  • The spectrum of activity of tafamidis is limited to ATTR, specifically to ATTR with polyneuropathy. It has been shown to slow the progression of neurological impairment in patients with early-stage ATTR polyneuropathy. tafamidis is ineffective in treating other types of amyloidosis or neuropathy. 

Contraindications/caution: 

Contraindications: 

None 

Caution: 

  • Liver function: tafamidis is primarily metabolized by the liver, so caution is advised in patients with liver dysfunction. Patients with moderate to severe hepatic impairment should be monitored closely for adverse effects. 
  • Pregnancy and breastfeeding: There is limited data on the safety of tafamidis use during pregnancy and breastfeeding, so caution should be exercised. 
  • Drug interactions: tafamidis is not known to interact with other medications. However, caution should be used when combined with drugs primarily metabolized by the liver or that may have hepatotoxic effects. 
  • Allergic reactions: Allergic reactions, including anaphylaxis, have been reported in patients taking tafamidis. Patients who develop signs of an allergic reaction should discontinue the medication and seek medical attention. 
  • Immunogenicity: There is a potential for patients to develop antibodies against tafamidis, which may reduce its effectiveness. Patients should be monitored for signs of decreased efficacy and the potential need for dose adjustments. 
  • Geriatric patients: While there are no specific cautions, they may be more likely to experience adverse effects due to age-related changes in drug metabolism and elimination. 

Pregnancy consideration: Insufficient data available 

Lactation: Excretion of the drug in human breast milk is unknown 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.   

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology:

tafamidis is a small molecule that selectively binds to transthyretin (TTR), a protein that plays a role in the transport of thyroid hormones and retinol-binding protein. In patients with TTR-mediated amyloidosis, mutations in the TTR gene can lead to unstable TTR tetramers, which can dissociate and form amyloid fibrils that accumulate in various tissues.

tafamidis binds to the thyroxine-binding sites of TTR, stabilizing the tetrameric structure of the protein and preventing its dissociation into monomers, which is a critical step in the formation of amyloid fibrils. By stabilizing the tetrameric structure, tafamidis reduces the misfolded TTR available to form tissue amyloid deposits.

Pharmacodynamics:

The pharmacodynamics of tafamidis is related to its mechanism of action, which is to stabilize the tetrameric structure of transthyretin (TTR) and prevent its dissociation into monomers. By doing so, tafamidis reduces the amount of misfolded TTR available to form amyloid fibrils, which can accumulate in various tissues and cause organ damage.

tafamidis has been shown to stabilize TTR tetramers in vitro and in vivo and reduce the dissociation rate of tetramers into monomers. In clinical studies, tafamidis has been shown to slow the progression of neuropathy in patients with TTR-mediated amyloidosis, with reductions in nerve impairment scores observed compared to placebo.

Pharmacokinetics:

Absorption

tafamidis is well-absorbed orally, and the peak plasma concentration is achieved 4 hours after administration. There are no clinically significant differences in the steady-state peak plasma concentration and AUC between the 61-mg capsule and the four 20-mg tafamidis meglumine capsules.

Distribution

tafamidis has a Vd (steady-state) of 18.5 L, indicating that it is widely distributed throughout the body. Over 99% of tafamidis is bound to plasma proteins, primarily to TTR.

Metabolism

The metabolism of tafamidis is not fully characterized, but it is known to undergo glucuronidation, a process by which glucuronic acid is added to the drug molecule, making it more water-soluble and easier to eliminate from the body.

Elimination and Excretion

tafamidis has a half-life of approximately 49 hours and an oral clearance of 0.263 L/hr. It is primarily eliminated through the feces, with about 59% of the drug being excreted unchanged in the feces. About 22% of the drug is eliminated in the urine, mainly as a glucuronide conjugate.

Administration:

Oral administration:

  • It may be consumed either with or without food
  • Swallow the pill whole; do not crush or cut it.
  • If a dosage is missed, either give it as soon as possible or skip it and take the following dose at the usually scheduled time; do not double the dose.

Storage:

Keep at room temperature (20-25°C [68-77°F]); excursions to 15-30°C (59-86°F) are acceptable.

Patient information leaflet

Generic Name: tafamidis

Why do we use tafamidis?

tafamidis is a medication used to treat a rare genetic disorder called transthyretin amyloidosis (ATTR), characterized by the buildup of abnormal proteins called amyloids in various tissues and organs throughout the body.

  • tafamidis is specifically approved for treating ATTR with cardiomyopathy, a disease that affects the heart.
  • tafamidis works by stabilizing the tetrameric structure of the transthyretin protein, which is the protein misfolded in ATTR. By stabilizing the protein, tafamidis helps to prevent the formation of amyloids and the subsequent damage to tissues and organs

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