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Brand Name :
Lotusate
Synonyms :
talbutal
Class :
Sedative and Hypnotic
Brand Name :
Lotusate
Synonyms :
talbutal
Class :
Sedative and Hypnotic
Dosage Forms & Strengths  Â
Tablet  Â
120mg  Â
Short- to intermediate-acting barbiturate talbutal was once used as a sedative and hypnotic, but the use was later discontinued.
Actions and Spectrum:Â Â Â
talbutal binds to GABAA receptors associated with a Cl- receptor. Upon binding, the tatbutal increases the time for Cl- to open, leading to a prolongled inhibitory effect of Gaba at the postsynaptic thalamic neuron.Â
Frequency defined  Â
Not available Â
Black box warning:Â Â Â
None Â
 Â
Contraindications/caution:Â Â Â
Contraindications:Â
Pregnancy Warnings:Â
Pregnancy category: Not available  Â
Lactation: Excretion of drug into breast milk is unknownÂ
Pregnancy Categories:Â Â Â
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.  Â
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.  Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.  Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.  Â
Category N: There is no data available for the drug under this category.  Â
Pharmacology:Â Â Â
talbutal binda to GABAA receptors associated with Cl- receptor. Upon binding, talbutal increases the time for Cl- to open, leading to a prolonged inhibitory effect of GABA at the postsynaptic thalamic neuron.Â
Pharmacodynamics:Â Â Â Â
talbutal is capable of producing CNS alternations from excitation to mild sedation, hypnosis, and deep coma. Barbiturates can also be used to induce anesthesia at high doses.Â
AbsorptionÂ
It is administered orally. Â
DistributionÂ
the drug gets distributed throughout the body. Â
MetabolismÂ
It undergoes hepatic metabolism with CYP450 enzymes including CYP1A2 and CYP3A4.
Excretion and EliminationÂ
The drug gets excreted through kidneys.Â
Administration:Â Â Â
oral administration. enprofylline is administered orally at same time every day. Â
 Â
Patient information leaflet  Â
Generic Name: talbutal  Â
Why do we use talbutal?  Â
talbutal is used to treat insomnia by inducing and maintaining regular sleep patterns.Â
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