tebipenem (Pending FDA Approval)

Action and Spectrum

Actions and Spectrum: 

Actions: 

Tebipenem is highly active against class A (including ESBLs) and class C-lactamase-transformed germs, but not against class B (metallolactamase)-transformed pathogens.Tebipenem is effective against class A (including ESBLs) and class C-lactamase-transformed strains, but not against class B (metallolactamase)-transformed strains. 

Spectrum: 

Tebipenem is an oral carbapenem antibiotic that has broad-spectrum efficacy against Gram-positive and -negative bacteria except for Pseudomonas aeruginosa. 

Drug Interaction

Adverse Reaction

N/A 

Black Box Warning

N/A  

Contraindication / Caution

N/A  

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Tebipenem, like other beta-lactam antibiotics, penetrates through the outer membrane into the periplasmic region. After acylation of tebipenem in the periplasmic region, penicillin-binding proteins (PBPs) are blocked. Thus, the production of cell wall peptidoglycan is catalyzed, weakening the peptidoglycan and resulting in bacterial cell lysis. 

Pharmacodynamics: N/A 

Pharmacokinetics: N/A 

Adminstartion

N/A 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tebipenem 

Pronounced: teh-bee-pen-em 

Why do we use tebipenem? 

Tebipenem is frequently used to treat severe infections such as complicated urinary tract infections (cUTI), complicated intra-abdominal infections (cIAI), and other complex illnesses that require a strong antibiotic.