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Brand Name :
Hepatolite
Synonyms :
technetium Tc-99m disofenin
Class :
Radiopharmaceutical
Brand Name :
Hepatolite
Synonyms :
technetium Tc-99m disofenin
Class :
Radiopharmaceutical
Dosage Forms & Strengths
Injection
20 mcg
Administer dose of 1 to 5 mCi intravenously
Dosing modification
Renal Impairment
No dose modification required
Hepatic Impairment
for serum bilirubin >5 mg/dL: dose of 3 to 8 mCi
Not determined
Refer to adult dosing
Actions and Spectrum
technetium Tc-99m disofenin consists of a chelating agent (disofenin) and the radioactive isotope technetium-99m.
The Tc-99m disofenin is taken up by the liver and excreted into the bile, like the normal metabolic process of the liver.
technetium Tc-99m emits gamma radiation, which is a type of electromagnetic radiation with high energy.
Frequency not defined
Itching at injection site
Erythema multiforme
Black Box Warning
None
Contraindication/Caution:
Contraindication:
None
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: technetium Tc 99m is present in human breast milk
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
technetium Tc-99m disofenin is transported through the bile ducts and ultimately reaches the gallbladder. It is stored in the gallbladder until the gallbladder contracts in response to a meal or hormonal stimulation.
Pharmacodynamics
The radiopharmaceutical agent is given to the liver sinusoids via the portal vein and hepatic artery and diffuses via the pores in the endothelial lining to attach to a particular membrane bound carrier, which carries the tracer over the hepatocyte membrane and into the hepatocyte 3.
Pharmacokinetics
Absorption
technetium Tc-99m disofenin is a radiopharmaceutical is directly introduced into the bloodstream.
Distribution
technetium Tc-99m disofenin circulates in the bloodstream and is distributed to various tissues.
Metabolism
technetium Tc-99m disofenin is not significantly metabolized within the body.
Elimination and excretion
The primary route of excretion for technetium Tc-99m disofenin is through the hepatobiliary system.
Administration
technetium Tc-99m disofenin is administered intravenously directly introduced into the bloodstream.
Patient information leaflet
Generic Name: technetium Tc-99m disofenin
Why do we use technetium Tc-99m disofenin?
technetium Tc-99m disofenin is used as a hepatobiliary imaging agent. It is also used to diagnose acute cholecystitis and to rule out the possibility of acute cholecystitis in patients who have right upper quadrant discomfort, fever, jaundice, right upper quadrant tenderness.
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