technetium Tc-99m gluceptate

Action and Spectrum

Actions and Spectrum 

The uptake of technectium Tc-99m gluceptate by the kidneys allows for the visualization and assessment of renal function and blood flow. The radioactive decay of Tc-99m results in the emission of gamma rays. 

Drug Interaction

Adverse Reaction

Frequency defined  

<1% 

Erythema 

Dyspnea 

Skin rash  

Vomiting  

Allergic dermatitis  

Nausea  

Flushing  

Hypersensitivity  

Pruritus

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

None  

Caution: 

• Caution is needed when using radiopharmaceuticals in patients with impaired renal function. 
• Caution should be taken in cases where multiple diagnostic tests involving radiation exposure are being considered. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: technetium Tc 99m is excreted into human breast milk 

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

technetium Tc-99m gluceptate acts as a chelating agent that binds to Tc-99m, forming a stable complex.  

The Tc-99m gluceptate complex is then preferentially taken up by the kidneys, where it is filtered by the glomeruli and excreted into the renal tubules.  

Pharmacodynamics 

technectium Tc-99m gluceptate complex emits gamma radiation as Tc-99m undergoes radioactive decay.  

The emitted gamma rays are used to create images that depict the distribution of the radiopharmaceutical in the body. 

Pharmacokinetics 

Absorption   

technetium Tc-99m gluceptate is rapidly enters the bloodstream after intravenous administration.  

Distribution 

technectium Tc-99m gluceptate circulates throughout the body. 

Metabolism 

technetium Tc-99m gluceptate is not significantly metabolized in the body.  

Elimination and excretion 

technectium Tc-99m gluceptate is primarily eliminated from the body through the urinary system. 

Adminstartion

Administration 

technetium Tc-99m gluceptate is typically administered intravenously as an injection into the bloodstream. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: technetium Tc-99m gluceptate 

Why do we use technetium Tc-99m gluceptate? 

technetium Tc-99m gluceptate used as brain imaging agent for evaluation of brain perfusion.  

technetium Tc-99m gluceptate used as kidney imaging agent for evaluation of renal perfusion.  

technetium Tc-99m gluceptate used as cardiac blood pool imaging agent.