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Brand Name :
Aubagio
Synonyms :
teriflunomide
Class :
Multiple Sclerosis Treatments; Pyrimidine Synthesis Inhibitors
Dosage forms & Strengths:Â
Adult:Â
Tablet:Â
7 mgÂ
7 - 14
mg
Tablet
Orally 
once a day
Safety and efficacy are not seen in pediatricsÂ
Safety and efficacy are not seen in pediatrics
It may diminish the serum concentration when combined with bile acid sequestrants
may decrease the serum concentration of active metabolites
when both drugs are combined, there may be a decreased level of serum concentration of etoposide   
when both drugs are combined, there may be an increased risk or severity of adverse effects  
when both drugs are combined, there may be a reduced metabolism of paclitaxel 
when both the drugs are combined, the serum concentration of carmustine decreases    
when both drugs are combined, there may be an increased risk or severity of adverse effects  
when both drugs are combined, there may be an increased risk or severity of adverse effects   
may enhance the serum concentration of OAT1/3 substrates
may enhance the serum concentration of OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors
may enhance the serum concentration of OAT1/3 Substrates
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
it may diminish the excretion rate when combined with zinc, resulting in an enhanced serum level
may have a decrease in excretion when combined with teriflunomide
>10%:Â
Headache Â
Diarrhea Â
Increased Â
AlopeciaÂ
Influenza Â
Nausea Â
Paresthesia Â
PhosphatemiaÂ
1-10%:Â
URTIÂ Â
Bronchitis Â
Upper abdominal pain Â
Sinusitis Â
Musculoskeletal pain Â
Hypertension Â
Toothache Â
Increased GGTÂ Â
Anxiety Â
Myalgia Â
Pruritus Â
Blurred vision Â
Cystitis Â
Viral gastroenteritis Â
Oral herpes Â
Neutropenia Â
Increased ASTÂ Â
Seasonal allergyÂ
Burning sensation Â
Palpitations Â
Decreased weight Â
Decreased neutrophil count Â
Sciatica Â
Conjunctivitis Â
Increased WBCÂ Â
Acne Â
Carpal tunnel syndrome Â
Leukopenia Â
<1%:Â
Cardiovascular DeathÂ
Teriflunomide is contraindicated in patients hypersensitive to the active ingredient.Â
Pregnancy consideration:Â Â
The drug is contraindicated during pregnancy. Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of the drug in breast milk.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: teriflunomideÂ
Pronounced: ter-i-flu-no-mideÂ
Why do we use teriflunomide?Â
Teriflunomide is used to treat multiple sclerosis.  Â