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tetrabenazine is a medication used for the symptomatic management of hyperkinetic movement disorders, including Huntington’s disease, tardive dyskinesia, and other related conditions.
It is a reversible and selective inhibitor of the vesicular monoamine transporter 2 (VMAT2) that depletes presynaptic monoamine stores, thereby reducing dopamine release in the brain.
tetrabenazine is believed to work by reducing the dopaminergic activity in the basal ganglia, which helps to reduce the involuntary movements that are characteristic of hyperkinetic disorders.