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Brand Name :
Mintezol, Foldan, Triasox
Synonyms :
thiabendazole
Class :
Anthelmintic
Not determined
Refer to adult dosing
bacitracin: it may decrease the excretion rate of thiabendazole
Actions and Spectrum
thiabendazole works by inhibiting the growth and reproduction of fungi. It interferes with the synthesis of the fungal cell wall and disrupting the fungal cell membrane. This disrupts the fungal cell’s structural integrity and leads to its death.
Frequency not defined
Upset stomach
Fever or chills
Ringing in the ears
Diarrhea
Dizziness
Vomiting
Loss of appetite
Numbness
Unusual urine odor
Drowsiness
Headache
Blurred vision or dryness of the eyes
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
thiabendazole disrupts the formation of microtubules in fungal cells, interfering with their structural integrity and functions. This disruption leads to inhibition of fungal growth and reproduction. The drug can also disrupt the integrity of fungal cell membranes, further contributing to cell death.
Pharmacodynamics
thiabendazole interferes with the energy metabolism of parasitic worms, including the inhibition of certain enzymatic reactions crucial for their survival.
This metabolic disruption immobilizes the worms and makes it easier for the host’s immune system to eliminate them.
Pharmacokinetics
Absorption
thiabendazole is absorbed relatively slow after oral intake.
Distribution
thiabendazole is distributed throughout the body.
Metabolism
thiabendazole is metabolized in the liver.
Elimination and excretion
thiabendazole is primarily excreted in the urine.
Administration
thiabendazole is available in the form of tablet for oral intake.
Patient information leaflet
Generic Name: thiabendazole
Why do we use thiabendazole?
Mintezol (thiabendazole) is used to treat infections caused by worms such as threadworm and parasitic worm infections.
thiabendazole is also used to treat pinworm hookworm, roundworm, and trichinosis.