thiethylperazine

Action and Spectrum

Actions and Spectrum 

thiethylperazine blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and the vomiting center in the brain.  

By inhibiting the transmission of nausea signals, it can help alleviate symptoms of nausea and vomiting.  

Drug Interaction

Adverse Reaction

Frequency not defined  

Difficulty breathing 

Headache  

Dizziness  

Closing of the throat 

Swelling of the lips, tongue, or face 

Drowsiness 

Confusion 

Yellowing of the skin or eyes 

Agitation  

Weakness 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• thiethylperazine should not be used in individuals with a known hypersensitivity or allergy to its components. 
• thiethylperazine is contraindicated in individuals in a coma or experiencing a severe depressed level of consciousness. 

Caution: 

• Use thiethylperazine with caution in individuals with a history of cardiovascular disease. 
• Caution is advised when using thiethylperazine in patients with liver disease. 
• thiethylperazine should be used cautiously in individuals with a history of seizure disorders. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

thiethylperazine also has anticholinergic properties. It can block the action of acetylcholine, a neurotransmitter, in various parts of the body. It has alpha-adrenergic blocking properties, which may contribute to its antiemetic and sedative effects. 

Pharmacodynamics 

thiethylperazine has alpha-adrenergic blocking properties, which can contribute to its antiemetic and sedative effects. Alpha-adrenergic receptors are involved in regulating various physiological processes, including blood pressure and smooth muscle contraction. It can cause sedation and drowsiness. This sedative effect can be beneficial in managing nausea. 

Pharmacokinetics 

Absorption   

thiethylperazine is absorbed in the gastrointestinal tract.  

Distribution 

thiethylperazine is distributed throughout the body.  

Metabolism 

thiethylperazine undergoes liver metabolism. 

Elimination and excretion 

thiethylperazine is excreted in the urine.

Adminstartion

Administration 

thiethylperazine is available in the form of oral tablets and injectable solutions. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: thiethylperazine 

Why do we use thiethylperazine? 

thiethylperazine is indicated to treat nausea and vomiting related to various causes, such as infectious gastroenteritis, migraine-associated nausea. thiethylperazine can be used to prevent and relieve motion sickness.