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Brand Name :
Torecan
Synonyms :
thiethylperazine
Class :
Phenothiazine antiemetics
Brand Name :
Torecan
Synonyms :
thiethylperazine
Class :
Phenothiazine antiemetics
Dosage Forms & Strengths
Solution
5mg/ml
Tablet
10 mg
Take a dose of 10 mg orally for one to three times daily as required
Dosage Forms & Strengths
Solution
5mg/ml
Tablet
10 mg
For >12 years old:
Take a dose of 10 mg orally for one to three times daily as required
Refer to adult dosing
Actions and Spectrum
thiethylperazine blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and the vomiting center in the brain.
By inhibiting the transmission of nausea signals, it can help alleviate symptoms of nausea and vomiting.
Frequency not defined
Difficulty breathing
Headache
Dizziness
Closing of the throat
Swelling of the lips, tongue, or face
Drowsiness
Confusion
Yellowing of the skin or eyes
Agitation
Weakness
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
thiethylperazine also has anticholinergic properties. It can block the action of acetylcholine, a neurotransmitter, in various parts of the body. It has alpha-adrenergic blocking properties, which may contribute to its antiemetic and sedative effects.
Pharmacodynamics
thiethylperazine has alpha-adrenergic blocking properties, which can contribute to its antiemetic and sedative effects. Alpha-adrenergic receptors are involved in regulating various physiological processes, including blood pressure and smooth muscle contraction. It can cause sedation and drowsiness. This sedative effect can be beneficial in managing nausea.
Pharmacokinetics
Absorption
thiethylperazine is absorbed in the gastrointestinal tract.
Distribution
thiethylperazine is distributed throughout the body.
Metabolism
thiethylperazine undergoes liver metabolism.
Elimination and excretion
thiethylperazine is excreted in the urine.
Administration
thiethylperazine is available in the form of oral tablets and injectable solutions.
Patient information leaflet
Generic Name: thiethylperazine
Why do we use thiethylperazine?
thiethylperazine is indicated to treat nausea and vomiting related to various causes, such as infectious gastroenteritis, migraine-associated nausea. thiethylperazine can be used to prevent and relieve motion sickness.
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