Impact of Maternal Eating Disorders on Pediatric Respiratory Health in Europe
December 10, 2025
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Brand Name :
Zadaxin
Synonyms :
thymalfasin
Class :
Protein based therapy
Brand Name :
Zadaxin
Synonyms :
thymalfasin
Class :
Protein based therapy
Dosage Forms & StrengthsÂ
Injectable solutionsÂ
1.6mg subcutaneously two times a week
For patients less than 40kgs- 40mcg/kg
Note: this can be used with interferon for chronic hepatitis C
Dosage Forms & StrengthsÂ
Safety and efficacy not establishedÂ
Refer to adult dosingÂ
Actions and SpectrumÂ
The exact mechanism is not fully understood, it is believed to increase the T-cell function by modulating the immune system.Â
Frequency not definedÂ
ErythemaÂ
Transient muscle atrophyÂ
Polyarthralgia with edema of handÂ
RashÂ
Reactions at the site of injectionÂ
Black Box WarningÂ
NoneÂ
Contraindication/CautionÂ
ContraindicationÂ
HypersensitivityÂ
CautionsÂ
Caution should be maintained when given with other immunomodulating agentsÂ
Pregnancy consideration:Â Â
USFDA pregnancy category: CÂ Â
Lactation:Â Â
Data about the excretion of thymalfasin into breast milk is not known.Â
Pregnancy category:Â Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester.Â
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category Â
PharmacologyÂ
It is an aminoacid peptide indicated in treating various ailments.Â
PharmacodynamicsÂ
It is a protein made up of 28 amino acids that was first found in bovine thymus extract along with other peptides that boost the immune system. Research done in a lab has demonstrated that it can influence the growth and advancement of T-cells which generates Th1 cytokines like interleukin-two and interferon-gamma. It also kickstart the natural killer cells’ ability to destroy harmful cells.Â
PharmacokineticsÂ
AbsorptionÂ
It is absorbed rapidlyÂ
Half lifeÂ
2 hoursÂ
AdministrationÂ
It should be administered subcutaneously only.Â
Patient information leafletÂ
Generic Name: thymalfasinÂ
Why do we use thymalfasin?Â
It is indicated as adjuvant therapy in treating chronic hepatitis B and C. It is also used in between chemotherapy cycles in cancer patients.Â
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