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Brand Name :
Zadaxin
Synonyms :
thymalfasin
Class :
Protein based therapy
Brand Name :
Zadaxin
Synonyms :
thymalfasin
Class :
Protein based therapy
Dosage Forms & Strengths
Injectable solutions
1.6mg subcutaneously two times a week
For patients less than 40kgs- 40mcg/kg
Note: this can be used with interferon for chronic hepatitis C
Dosage Forms & Strengths
Safety and efficacy not established
Refer to adult dosing
Actions and Spectrum
The exact mechanism is not fully understood, it is believed to increase the T-cell function by modulating the immune system.
Frequency not defined
Erythema
Transient muscle atrophy
Polyarthralgia with edema of hand
Rash
Reactions at the site of injection
Black Box Warning
None
Contraindication/Caution
Contraindication
Hypersensitivity
Cautions
Caution should be maintained when given with other immunomodulating agents
Pregnancy consideration:
USFDA pregnancy category: C
Lactation:
Data about the excretion of thymalfasin into breast milk is not known.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester.
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
It is an aminoacid peptide indicated in treating various ailments.
Pharmacodynamics
It is a protein made up of 28 amino acids that was first found in bovine thymus extract along with other peptides that boost the immune system. Research done in a lab has demonstrated that it can influence the growth and advancement of T-cells which generates Th1 cytokines like interleukin-two and interferon-gamma. It also kickstart the natural killer cells’ ability to destroy harmful cells.
Pharmacokinetics
Absorption
It is absorbed rapidly
Half life
2 hours
Administration
It should be administered subcutaneously only.
Patient information leaflet
Generic Name: thymalfasin
Why do we use thymalfasin?
It is indicated as adjuvant therapy in treating chronic hepatitis B and C. It is also used in between chemotherapy cycles in cancer patients.
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