tildipirosin

Action and Spectrum

Actions and spectrum: 

Tildipirosin has antibacterial properties, so they bind to the 50S subunit of bacterial ribosomes. It inhibits the protein synthesis in susceptible bacteria. 

Drug Interaction

Adverse Reaction

Frequency not determined 

Allergic reactions 

Black Box Warning

Black Box Warning:

there is no specific black box warning for tildipirosin.

Contraindication / Caution

Contraindication/Caution: 

The drug should be contraindicated in following situations: 

Hypersensitivity 

Use in Non-Target Species 

Presence of Resistant Bacterial Strains 

Pregnancy / Lactation

Pregnancy Warnings:  

Pregnancy category: N/A  

Lactation:  

Excretion of the drug in human breast milk is unknown  

Pregnancy Categories:    

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.    

<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.    

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.    

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.    

Category N: There is no data available for the drug under this category.   

Pharmacology

Pharmacology: 

It mainly inhibits bacterial protein synthesis, and it binds with 50S ribosomal subunit.  

Pharmacodynamics: 

The drug interferes with the movement of transfer RNA. This interaction disrupts the elongation of protein synthesis. 

Pharmacokinetics: 

Absorption:  

Tildipirosin is administered through injection, and its absorption occurs at the site of injection.  

Distribution:  

It is distributed throughout the body. 

Metabolism:  

It undergoes primarily hepatic metabolism. 

Excretion:  

The drug is eliminated in bile and feces.  

Adminstartion

Administration: 

The drug is given as injectables solution specifically in intramuscular and subcutaneous route.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: tildipirosin 

Why do we use tildipirosin? 

Tildipirosin is indicated in the treatment of bovine respiratory disease complex in cattle.