- June 3, 2022
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Brand Name :
APO-Tobramycin, Crown Ak-Tobra, SANDOZ Tobramycin, Tobrex
Synonyms :
Class :
Antibiotics & Aminoglycoside
Dosage forms & Strengths
Solution, Ophthalmic:
3.5 g (0.3%)
Ointment, Ophthalmic:
0.3% (5 ml)
Mild to moderate infections:
Ointment: Apply half-inch to affected areas 2 to 3 times daily every 8 to 12 hrs
Solution: 1 to 2 drops in affected eyes every 4 hrs
Severe infections:
Ointment: Apply half-inch to affected areas 2 to 3 times daily every 3 to 4 hrs
Solution: 1 to 2 drops in affected eyes every 12hrs, for infection associated with pseudomonas aeruginosa every 5 to 30 minutes (depends on the symptoms)
No dosage adjustment was described for renal/hepatic impairment
Dosage forms & Strengths
Solution, Ophthalmic:
3.5 g (0.3%)
Ointment, Ophthalmic:
0.3% (5 ml)
Refer to adult dosing
may diminish the serum concentration of pencillins
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
may increase the serum concentration of Cardiac Glycosides
they increase the effect of hypocalcemia in bisphosphonate derivatives
they increase the effect of hypocalcemia in bisphosphonate derivatives
they increase the effect of hypocalcemia in bisphosphonate derivatives
they increase the effect of hypocalcemia in bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
may enhance the hypocalcemic effect of bisphosphonate derivatives
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
cephalosporins increase the nephrotoxicity of aminoglycosides
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may enhance the therapeutic effect of neuromuscular-blocking agents
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may diminish the excretion when combined with aminoglycosides
may enhance the hypocalcemic effect
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
may increase the therapeutic effect of neuromuscular-blocking agents
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of aminoglycosides.
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may decrease the excretion of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may enhance the nephrotoxic effect of aminoglycosides
may decrease the excretion of non-steroidal anti-inflammatory drugs
loop diuretics may increase the risk of adverse effect of aminoglycosides
loop diuretics may increase the risk of adverse effect of aminoglycosides
loop diuretics may increase the risk of adverse effect of aminoglycosides
may increase the nephrotoxic effect of aminoglycosides
may increase the nephrotoxic effect of aminoglycosides
may increase the nephrotoxic effect of aminoglycosides
may increase the nephrotoxic effect of cephalosporins
may increase the anticoagulant effect of cephalosporins
may decrease the excretion of nonsteroidal anti-inflammatory agents
may have an increased neuromuscular-blocking effect when combined with botulinum toxin-containing products
may enhance the nephrotoxicity of aminoglycosides
may have an increased nephrotoxic effect when combined with aminoglycosides
may increase the nephrotoxic effect of Amphotericin B
Frequency defined:
<1%:
Hypersensitivity reaction
Eyelid edema
Eyelid pruritis
Conjunctival erythema
Postmarketing:
Erythema multiforme
Stevens-johnson syndrome
Anaphylaxis
Pregnancy consideration: Tobramycin (ophthalmic) can be assigned under pregnancy category N. Ophthalmic solutions show zero to minimal effects on pregnant females.
Lactation: No data available regarding the excretion of tobramycin in breast milk.
Pregnancy category:
Patient information leaflet
Generic Name: Tobramycin
Pronounced: To-bra-mi-cin
Why do we use tobramycin?
Tobramycin is an aminoglycoside antibiotic. The ophthalmic dosage form of tobramycin is used to treat mild to severe eye infections.
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