tolnaftate

Action and Spectrum

Actions and Spectrum: 

In terms of actions, tolnaftate works by inhibiting the growth and spread of fungal cells, ultimately leading to their death. This action helps to eliminate the fungal infection and relieve associated symptoms such as itching and redness. 

Regarding spectrum, tolnaftate is generally effective against dermatophyte fungi, the most common cause of fungal skin infections. However, it may not be effective against all types of fungi or in treating more severe or widespread infections. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Sensitization 

Mild irritation 

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

• Allergy: People allergic to tolnaftate should not use this medication. 
• Children: tolnaftate is generally safe for children over two, but you should consult with a healthcare professional before using this medication on a child. 
• Interactions: Tell your healthcare professional about all medications, supplements, and herbal remedies you are taking before starting a new medication. 
• Caution: tolnaftate is intended for external use only and should not be applied to broken or irritated skin. If the symptoms don’t improve after applying tolnaftate for a few weeks, or if your symptoms get worse, you should consult a healthcare professional. Additionally, you may need a more potent medication or a different treatment approach if you have a severe or widespread fungal infection. 

Pregnancy / Lactation

Pregnancy consideration:  

No studies performed 

Breastfeeding warnings:  

Safety unknown  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: No evidence of risk to the fetus is found in animal reproduction studies, and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a human product; Pregnant women must take care of the potential risks. 
• Category D: There is adequate data with sufficient evidence of human fetal risk from various platforms. However, despite potential dangers may be used only in emergencies for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. The drug is not for pregnant women. 
• Category N: No data for the drug under this category is available. 

Pharmacology

Pharmacology: 

tolnaftate is an antifungal medication that inhibits the growth and spread of fungal cells. It does this by interfering with the function of certain enzymes within the fungal cell membrane, ultimately leading to its death. 

tolnaftate is a broad-spectrum antifungal medication effective against many fungal organisms. It primarily treats dermatophyte infections, the most common cause of fungal skin infections. 

When applied topically to the affected area, tolnaftate is slowly absorbed into the skin and the underlying tissues. It has a long duration of action, which means it can continue to provide antifungal protection for several hours after application. 

tolnaftate is available in various formulations, including creams, ointments, powders, and sprays. It is generally well-tolerated, with minimal side effects. Common side effects may include mild burning, itching, or irritation at the application site. 

Pharmacodynamics: 

The pharmacodynamics of tolnaftate involves its mechanism of action and its effects on the body. tolnaftate is an antifungal medication that belongs to the class of synthetic thiocarbamates. 

The mechanism of action of tolnaftate involves its ability to disrupt the cell membrane of fungal cells. It inhibits the activity of an enzyme called squalene epoxidase, which is necessary for the synthesis of ergosterol, a component of the fungal cell membrane. Without ergosterol, the fungal cell membrane becomes weakened, leading to leakage of cellular contents and eventual cell death. 

tolnaftate is active against dermatophytes, the most common fungi responsible for skin and nail infections. It also has some activity against yeast and some non-dermatophyte molds. 

Pharmacokinetics: 

The drug is topically used; hence no pharmacokinetics are indicated. 

Adminstartion

Administration: 

tolnaftate is a medication that is typically applied topically to the affected area of the skin. Here are some general guidelines for the administration of tolnaftate: 

• Clean and dry the affected area: Before applying tolnaftate, ensure the affected skin area is clean and dry. It will help the medication to penetrate the skin more effectively. 
• Apply the medication: Apply a thin layer of tolnaftate to the affected area, rubbing it in gently until it is absorbed. Be sure to follow the dosage instructions provided by your healthcare professional or the instructions on the product label. 
• Wash your hands: After applying tolnaftate, wash your hands thoroughly to avoid accidentally transferring the medication to other areas of your body or other people. 
• Use as directed: Using tolnaftate as directed by your healthcare professional or as indicated on the product label is essential. It may involve applying the medication once or twice daily for several weeks or until symptoms improve. 
• Store the medication properly: Store tolnaftate in a cool, dry place, away from direct sunlight and heat. Be sure to keep it out of reach of children and pets. 

Patient Information Leaflet

Patient information leaflet 

Generic Name:  tolnaftate 

Pronounced: toll-NAF-tate 

Why do we use tolnaftate? 

tolnaftate is used primarily to treat fungal infections of the skin and nails. It is particularly effective against dermatophyte fungi, the most common cause of fungal skin infections. Dermatophytes are fungi that can infect the skin, hair, and nails, causing symptoms such as itching, scaling, redness, and thickening. 

tolnaftate works by inhibiting the growth and spread of fungal cells. It does this by interfering with the function of certain enzymes within the fungal cell membrane, ultimately leading to its death. tolnaftate is a broad-spectrum antifungal medication effective against a wide range of fungal organisms. 

tolnaftate is available in various formulations, including creams, ointments, powders, and sprays. It is generally well-tolerated, with minimal side effects. Common side effects may include mild burning, itching, or irritation at the application site.