tongkat ali

Action and Spectrum

Actions and Spectrum: 

In terms of its actions, tongkat ali increases testosterone levels in men, increasing muscle mass, strength, and endurance. It may also improve sexual function and libido in both men and women.

Additionally, tongkat ali has anti-inflammatory and antioxidant properties. The spectrum of tongkat ali’s effects is broad, with research suggesting that it may have several potential benefits.

Drug Interaction

Adverse Reaction

Frequency not  defined 

Restlessness 

Irritability 

Insomnia 

Black Box Warning

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hepatic impairment 
• Renal impairment 
• Cardiac disease 
• Hormone-sensitive cancers 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

The drug is not indicated during pregnancy.  

Breastfeeding warnings:  

Lactation is contraindicated during drug therapy. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show fetal risks in the first or later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

The primary active compounds in tongkat ali are quassinoids and eurycomanone, which have been shown to have anti-inflammatory, antioxidant, and pro-androgenic effects. 

Quassinoids are believed to stimulate testosterone production by promoting the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones, in turn, stimulate the Leydig cells in the testes to produce more testosterone. Quassinoids also have anti-estrogenic effects, which may further enhance testosterone production.  

Pharmacodynamics: 

One of the primary pharmacodynamic effects of tongkat ali is its ability to increase testosterone levels. Testosterone plays a crucial role in male sexual function, muscle mass, bone density, and red blood cell production. tongkat ali stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which stimulates the Leydig cells in the testes to produce more testosterone.

tongkat ali’s effects on testosterone levels can lead to several other pharmacodynamic effects. For example, increased testosterone levels may improve muscle mass, strength, and endurance and enhance athletic performance. It may also improve sexual function and libido in both men and women. 

tongkat ali also has anti-inflammatory and antioxidant effects, which may contribute to its pharmacodynamic effects. 

Pharmacokinetics: 

Absorption 

The active compounds in tongkat ali, such as quassinoids and eurycomanone, are absorbed into the bloodstream through the gastrointestinal tract after oral ingestion.  

Distribution 

The drug is distributed throughout the body. 

Metabolism 

It is also believed that tongkat ali is metabolized in the liver. 

Elimination and Excretion 

The metabolites are excreted from the body through the urine and feces.

Adminstartion

Administration: 

tongkat ali is typically consumed in supplement form, either as a powder, capsule, or liquid extract. It may also be found in energy drinks, protein powders, and other dietary supplements. 

The recommended dosage of tongkat ali can vary depending on the product and the individual’s health needs. Following the manufacturer’s instructions or consulting a healthcare professional for appropriate dosing is essential. 

tongkat ali supplements may be taken with or without food.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: tongkat ali 

Pronounced: Tong-kat ah-lee 

Why do we use tongkat ali ? 

tongkat ali is used for various health purposes, primarily related to its potential to improve male sexual function, muscle mass and strength, and overall vitality. Uses of tongkat ali are- 

• Male sexual health: tongkat ali is believed to help improve sexual function in men, particularly by increasing testosterone levels. This may lead to improved libido, erectile function, and overall sexual satisfaction. 
• Athletic performance: tongkat ali may help improve athletic performance by increasing muscle mass, strength, and endurance. 
• Overall vitality: tongkat ali is sometimes used as a general tonic to improve energy levels, reduce fatigue, and enhance overall vitality. 
• Stress and anxiety: tongkat ali may have anxiolytic effects, which may help reduce stress and anxiety levels. 
• Cognitive function: tongkat ali may have neuroprotective effects and improve cognitive function, including memory, attention, and learning ability. 
• Anti-inflammatory and antioxidant effects: tongkat ali may help reduce inflammation and oxidative stress, which are implicated in many chronic diseases.