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Brand Name :
SYD985 (in the pipeline)
Synonyms :
trastuzumab duocarmazine
Class :
Antineoplastics, Anti-HER2; Antineoplastics, Monoclonal Antibody
Brand Name :
SYD985 (in the pipeline)
Synonyms :
trastuzumab duocarmazine
Class :
Antineoplastics, Anti-HER2; Antineoplastics, Monoclonal Antibody
Dosage Forms & Strengths
Indicated for locally advanced/metastatic breast cancer that HER2-positive unresectable
Indicated for locally advanced/metastatic breast cancer that HER2-positive unresectable
The drug is pending FDA approval
Safety and efficacy are not seen in pediatrics
Refer to adult dosing
Actions and Spectrum:
Antibody-drug conjugate/ADC comprises an anti-HER2 monoclonal antibody. It also consists of a cleavable linker drug Azaindole (vc-seco-DUBA) called valine-citrulline-seco-DUocarmycin-hydroxyBenzamide-The part of this antibody binds to HER2 on the cancerous cells surface. DNA damage starts after activation of cytotoxin that causes tumor lysis.
None
Black Box Warning:
The drug is still under trial
Contraindication/Caution:
None is available.
Pregnancy consideration:
No adequate data are available regarding the usage of the drug during pregnancy.
Breastfeeding warnings:
No data on the drug’s effect on the infant during breastfeeding is available.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
None reported
Administration
The drug is given intravenously in a cycle of 3 weeks. It is still pending for approval.
Patient information leaflet
Generic Name: trastuzumab duocarmazine
Pronounced: tras-TOO-zoo-mab doo-o-kaar-mah-zeen
Why do we use trastuzumab duocarmazine?
trastuzumab duocarmazine is used to treat benign or metastatic breast cancer.
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