- March 15, 2022
- Newsletter
- 617-430-5616
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Brand Name :
Trazodone D, Oleptro, Desyrel Dividose, Desyrel
Synonyms :
Trazodonum, Trazodona
Class :
Antidepressants and antianxiety drugs; Atypical antidepressants
Brand Name :
Trazodone D, Oleptro, Desyrel Dividose, Desyrel
Synonyms :
Trazodonum, Trazodona
Class :
Antidepressants and antianxiety drugs; Atypical antidepressants
Dosage Forms & Strengths
Tablet
50mg
100mg
150mg
300mg
Extended-release tablet
150mg
300mg
Dosage Forms & Strengths
Tablet
50mg
100mg
150mg
300mg
Extended-release tablet
150mg
300mg
Dosage Forms & Strengths
Tablet
50mg
100mg
150mg
300mg
Extended-release tablet
150mg
300mg
gilteritinib may enhance the QTc-prolonging effect of QT-prolonging Agents
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the QTc-prolonging effect of QT-prolonging agents
may enhance the QTc-prolonging effect of QT-prolonging agents
may enhance the QTc-prolonging effect of QT-prolonging agents
may enhance the QTc-prolonging effect of QT-prolonging agents
may enhance the QTc-prolonging effect of QT-prolonging agents
may increase the QTc prolonging effect
may increase the QTc prolonging effect
may have an increased QTc-prolonging effect when combined with amisulpride (oral)
may increase the QTc prolonging effect of QT-prolonging agents
may have an increased QTc-prolonging effect when combined with amiodarone
may have an increased QTc-prolonging effect when combined with delamanid
CYP3A strong enhancers of the small intestine may reduce the bioavailability of trazodone
when used together, entrectinib and trazodone both increase the QTc interval
when used together, encorafenib and trazodone both increase the QTc interval
it may enhance the QTc-prolonging effect of terfenadine
may have an increased QTc-prolonging effect when combined with QT-prolonging agents
may have an increased QTc-prolonging effect when combined with QT-prolonging agents
may have an increased QTc-prolonging effect when combined with pazopanib
may enhance the QTc-prolonging effect of QT-prolonging Miscellaneous Agents
may enhance the QTc-prolonging effect of QT-prolonging Miscellaneous Agents
may enhance the QTc-prolonging effect of QT-prolonging Miscellaneous Agents
may enhance the QTc-prolonging effect of QT-prolonging Miscellaneous Agents
may enhance the QTc-prolonging effect of QT-prolonging Miscellaneous Agents
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
Selective Serotonin Reuptake Inhibitors may enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may enhance the antiplatelet effect of NSAIDs
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may enhance the risk of adverse effect of amphetamines
may increase the vasopressor effect
may enhance the tachycardic effect
may enhance the tachycardic effect
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
the effect of trazodone is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
decrease level of docetaxel
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
increase the therapeutic effect of idarubicin by P-glycoprotein efflux transporter
may enhance the Qtc prolonging effect
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
they increase the QTc prolongation effect of other QT-prolonging agents
may increase the QTc prolonging effect of QTc prolonging agents
may have an increased QTc-prolonging effect when combined with haloperidol
may increase the antiplatelet effect of nonsteroidal anti-inflammatory agents
may increase the serotonergic effect of Serotonin 5-HT1D Receptor Agonists
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the serotonergic effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
trazodone and dicyclomine decrease the cholinergic transmission
may increase the level of each other by unknown mechanism
Actions and Spectrum:
trazodone is an antidepressant medication that belongs to the class of drugs known as serotonin receptor antagonists and reuptake inhibitors (SARIs). It is primarily used to treat major depressive disorder (MDD). Still, it is also used off-label to treat other conditions, such as anxiety disorders, obsessive-compulsive disorder (OCD), and insomnia.
trazodone acts as a serotonin receptor antagonist and reuptake inhibitor, which means that it enhances the effects of serotonin in the brain by blocking its reuptake and increasing its release. Serotonin is a neurotransmitter that regulates mood, anxiety, and sleep, and enhancing its effects is believed to be the mechanism by which trazodone produces its therapeutic effects.
In addition to its effects on serotonin, trazodone has sedative and hypnotic effects due to its antagonism of histamine H1 receptors, contributing to its use in treating insomnia.
Trazodone also acts as an antagonist at the 5-HT2A receptor and a partial agonist at the 5-HT1A receptor, which may contribute to its anxiolytic and antidepressant effects.
Frequency Defined
>10%
Blurred vision
Dizziness
Fatigue
Headache
Drowsiness
Dry mouth
Nausea/vomiting
1-10%
Constipation
Edema
Incoordination
Nasal congestion
Confusion
Disorientation
Orthostatic hypotension
Syncope
Ejaculation disorder
Tremor
Weight change
Decreased libido
<1%
Priapism
Sedation
Acne
Anemia
Alopecia
Anxiety
Increased appetite
Diplopia
Vertigo
Insomnia
Urinary retention
Black Box Warning:
trazodone increases the risk of suicidal thoughts and alters behavior in young adults. The drug is not meant for pediatrics.
Contraindication/Caution:
Contraindications:
Cautions:
Pregnancy consideration:
trazodone should be used during pregnancy only when very much required.
Breastfeeding warnings:
Use the drug cautiously during lactation.
Pregnancy category:
Pharmacology:
trazodone is an antidepressant medication that belongs to the class of drugs known as serotonin receptor antagonists and reuptake inhibitors (SARIs). It works by increasing serotonin levels in the brain, a neurotransmitter that regulates mood, anxiety, and sleep.
The primary mechanism of action of trazodone is the inhibition of serotonin reuptake. This increases the concentration of serotonin in the synaptic cleft, which enhances the transmission of serotonin-mediated signals. Additionally, trazodone acts as an antagonist at the 5-HT2A receptor and a partial agonist at the 5-HT1A receptor. These actions contribute to the antidepressant and anxiolytic effects of trazodone.
trazodone also has sedative and hypnotic effects due to its antagonism of histamine H1 receptors, which is responsible for its use in the treatment of insomnia.
Pharmacodynamics:
The pharmacodynamics of trazodone refers to how the drug interacts with the body and produces its therapeutic effects. trazodone is primarily used to treat depression, anxiety, and sleep disorders.
trazodone acts as a serotonin receptor antagonist and reuptake inhibitor (SARI), which means that it enhances the effects of serotonin in the brain by blocking its reuptake and increasing its release. Serotonin is a neurotransmitter that regulates mood, anxiety, and sleep, and enhancing its effects is believed to be the mechanism by which trazodone produces its therapeutic effects.
In addition to its effects on serotonin, trazodone has sedative and hypnotic effects due to its antagonism of histamine H1 receptors, contributing to its use in treating insomnia.
trazodone also acts as an antagonist at the 5-HT2A receptor and a partial agonist at the 5-HT1A receptor, which may contribute to its anxiolytic and antidepressant effects.
The therapeutic effects of trazodone are believed to result from a combination of these mechanisms of action. By enhancing the effects of serotonin and modulating its effects on various receptor subtypes, trazodone helps to regulate mood, reduce anxiety, and improve sleep quality.
Pharmacokinetics:
Absorption
The drug is completely absorbed (absorption increases by food)
The onset of the action takes in 6 weeks (antidepressant); 1-3 hours help in sleep
A peak serum concentration is achieved in 30-100 min (up to 2.5 hours with food); and 9 hours (for extended-release)
480-1620 ng/mL of concentration is dose-dependent
Distribution
Protein-bound is 85-95%
Metabolism
Metabolism occurs via hepatic P450 enzyme and CYP3A4 (major) and CYP2D6 (minor)
Metabolites formed are l-m-chlorophenyl piperazine
Elimination and Excretion
The half-life is achieved in 7-10 hours
75% is excreted in urine, and 25% is excreted in feces
The drug is not dialyzable
Administration:
trazodone is typically administered orally in tablet form. The tablets should be swallowed whole with a full glass of water and may be taken with or without food.
The recommended starting dose of trazodone for depression is usually 150 mg daily, divided into two or three doses. Dose may gradually increase to a maximum daily dose of 400 mg over time. For the treatment of insomnia, lower doses of trazodone, typically 25-50 mg, may be used at bedtime.
trazodone should be taken at the same time(s) each day to maintain a steady level in the body. It is essential to follow the dosing instructions provided by your healthcare provider and stay within the recommended dose.
trazodone may take several weeks to reach its full therapeutic effect, and it is essential to continue taking the medication as directed even if you feel better.
Patient information leaflet
Generic Name: trazodone
Pronounced: tra-zo-done
Why do we use trazodone?
trazodone is primarily used to treat major depressive disorder (MDD). Still, it is also used off-label to treat other conditions, such as anxiety disorders, obsessive-compulsive disorder (OCD), and insomnia.
trazodone is an antidepressant medication that belongs to the class of drugs known as serotonin receptor antagonists and reuptake inhibitors (SARIs). It increases serotonin levels in the brain, a neurotransmitter that regulates mood, anxiety, and sleep. By enhancing serotonin’s effects, trazodone helps regulate mood, reduce anxiety, and improve sleep quality.
In addition to its effects on serotonin, trazodone has sedative and hypnotic effects due to its antagonism of histamine H1 receptors, contributing to its use in treating insomnia.
trazodone is generally well-tolerated, and it may be a good choice for patients who do not respond to other antidepressant medications or who experience intolerable side effects from other medications. It is also sometimes used with other medications, such as selective serotonin reuptake inhibitors (SSRIs), to augment their effects.