tribenoside/ lidocaine

Action and Spectrum

Actions and Spectrum: 

tribenoside 

tribenoside is a synthetic organic compound with anti-inflammatory and venotonic properties, it is thought to function by lowering inflammation and enhancing blood vessel tone and suppleness, particularly in the rectal area. This action helps to alleviate the symptoms associated with hemorrhoids, such as pain, swelling, and discomfort. 

lidocaine 

lidocaine is a local anesthetic that functions by inhibiting nerve signals within the region where it is administered. It is used to provide pain relief and numbing in the rectal and anal region, which can be particularly helpful in cases of hemorrhoids and anal fissures where pain and discomfort are common symptoms. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Rash 

Increased bowel motility 

Mild pain 

Burning sensation 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity: Do not use tribenoside/lidocaine if you have a known hypersensitivity or allergy to any of its components, including tribenoside or lidocaine. 

Skin Infections: Do not use this medication on areas of the skin that have active infections, open wounds, or ulcerations. It should not be applied to mucous membranes or the eyes. 

Pediatric Use: The safety and efficacy of tribenoside/lidocaine in children and infants have not been established. It is typically not recommended for use in pediatric patients. 

Pregnancy and Breastfeeding: The use of tribenoside/lidocaine during pregnancy and breastfeeding should be discussed with a healthcare provider. In some cases, it may be prescribed if the potential benefits outweigh the risks. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

tribenoside is a synthetic compound that belongs to the class of drugs known as venotonics or venoactive agents. lidocaine is a local anesthetic that belongs to the class of drugs known as amide-type anesthetics. 

Pharmacodynamics:  

tribenoside 

tribenoside works by boosting the contractile activity of smooth muscles situated in the inner linings of blood vessels. This mechanism serves to alleviate venous congestion and enhance the circulation of blood. 

It enhances the integrity of the connective tissues within blood vessels, potentially reducing the likelihood of blood components leaking into adjacent tissues. 

lidocaine 

lidocaine’s action involves the inhibition of voltage-gated sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. 

When administered as a topical treatment, lidocaine functions by desensitizing the region of its application, inhibiting the conveyance of pain signals from nerve endings to the central nervous system. 

Pharmacokinetics: 

Absorption 

tribenoside is typically administered orally. It is absorbed from the gastrointestinal tract and enters systemic circulation. 

lidocaine can be administered via various routes, including topical application, injection, or as a transdermal patch. The rate and extent of absorption depend on the administration method. 

Distribution 

Once in the bloodstream, tribenoside is distributed throughout the body. It may undergo binding to plasma proteins. 

lidocaine quickly enters the bloodstream and is distributed throughout the body. It may also bind to plasma proteins. 

Metabolism 

tribenoside may undergo metabolism in the liver, primarily by enzymes like cytochrome P450. The exact metabolic pathways and metabolites can vary. 

lidocaine is primarily metabolized in the liver by enzymes like cytochrome P450.  

Excretion and Elimination 

Metabolized tribenoside and its metabolites are excreted through the urine and feces. The exact elimination half-life can depend on factors like the formulation and individual patient characteristics. 

lidocaine and its metabolites are primarily excreted through the urine. The elimination half-life of lidocaine can vary but is generally relatively short. 

Adminstartion

Administration:  

If the medication is in cream or ointment form, squeeze a small amount (as prescribed) onto your fingertip or an applicator.  

If using an applicator, gently insert it into the rectum or apply it to the affected external area, as instructed.  

Carefully insert the applicator or your finger into the rectum and apply the medication.  

For external use, apply the medication gently to the affected area around the anus. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tribenoside/lidocaine 

Why do we use tribenoside/lidocaine?  

tribenoside/lidocaine is commonly recommended to relieve the symptoms related to hemorrhoids, which may include sensations like itching, burning, pain, and general discomfort. It helps reduce inflammation and soothe the affected area.  

In some cases, tribenoside/lidocaine is also applicable for the treatment of anal fissures, which refer to minor tears in the lining of the anus. The lidocaine component helps ease the pain associated with fissures.