triclocarban

Action and Spectrum

Actions and Spectrum 

triclocarban is effective against a wide range of bacteria. It works by disrupting the cell membranes of bacteria, which leads to their death. It primarily targets Gram-positive bacteria but can also have some activity against Gram-negative bacteria.

Drug Interaction

Adverse Reaction

Frequency not defined  

None 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have a known allergy or sensitivity to triclocarban should avoid products containing this chemical.  

Caution: 

• The use of products containing triclocarban on infants and young children are not advisable.  
• The overuse of products containing triclocarban can lead to the development of resistant bacteria. 
• Avoid any type of contact with the eye while using it.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

triclocarban works by disrupting the cell membranes of bacteria and fungi, leading to their death. 

It interferes with the microbial fatty acid synthesis pathway, which is essential for the formation and maintenance of cell membranes in these microorganisms. 

Pharmacodynamics 

triclocarban has antimicrobial effects that are active while it is in contact with the skin and the target microorganisms.  

This disruption of cell membranes leads to cell death in bacteria and fungi and makes triclocarban effective at reducing the growth and presence of these microorganisms on the skin. 

Pharmacokinetics 

Limited information available on ADME. 

Adminstartion

Administration 

triclocarban is available in form of soap for topical use. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: triclocarban 

Why do we use triclocarban? 

Neko (triclocarban) is used in soaps and body washes as an antimicrobial ingredient.  

triclocarban is intended to reduce the growth of bacteria and fungi on the skin, providing a sense of cleanliness.   

It also helps in keeping the skin odour and germ free, supple, and soft.