trimetazidine

Action and Spectrum

Actions and Spectrum 

trimetazidine is known as a metabolic modulator. It exerts its effects by inhibiting the enzyme 3-ketoacyl-CoA thiolase. 

This shift in energy substrate preference increases glucose oxidation, which is more oxygen-efficient than fatty acid oxidation.

Drug Interaction

Adverse Reaction

Frequency not defined  

Palpitations 

Tachycardia  

Nausea 

vomiting  

Abdominal pain 

Dyspepsia 

Asthenia 

Headache  

Dizziness 

Rash 

Urticaria 

Pruritus 

Arterial hypotension 

Orthostatic hypotension  

Flushing 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• trimetazidine is contraindicated in individuals with a known hypersensitivity or allergy to the active ingredient or any other components.  

Caution: 

• Patients with mild to moderate renal impairment should be used with caution. 
• trimetazidine should be used with caution in patients with liver disease or impaired liver function. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

trimetazidine reduces myocardial ischemia i.e., insufficient blood supply to the heart muscle.  

The heart is dependent on glucose, which requires less oxygen to produce energy compared to fatty acids. 

Pharmacodynamics 

Glucose metabolism is more oxygen-efficient than fatty acid metabolism. Which means the heart can generate the same amount of ATP for contraction with less oxygen consumption. 

Pharmacokinetics 

Absorption   

trimetazidine is well-absorbed from the gastrointestinal tract after oral administration. 

Distribution 

trimetazidine is distributed widely throughout the body. 

Metabolism 

trimetazidine undergoes extensive metabolism in the liver. 

Elimination and excretion 

trimetazidine is excreted through urine. 

Adminstartion

Administration 

trimetazidine is administered orally in tablet or capsule form.

Patient Information Leaflet

Patient information leaflet 

Generic Name: trimetazidine 

Why do we use trimetazidine? 

trimetazidine is used in treatment of stable angina pectoris.   

trimetazidine may be used as an adjunctive treatment of coronary artery disease (CAD).