- March 15, 2022
- Newsletter
- 617-430-5616
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Brand Name :
Primsol, Proloprim, Trimpex
Synonyms :
Class :
Urinary anti-infectives
Dosage Forms and Strengths:
oral solution
50 mg/5 ml
oral tablet
100 mg
100
mg
Orally
every 12 hrs
The maximum duration of therapy is 10 days
Dosage Forms and Strengths:
oral solution
50 mg/5 ml
oral tablet
100 mg
Age: >12 years
100 mg orally every 12 hours
The maximum duration of therapy is 10 days
Age: >6 months
5 mg/kg orally every 12 hours
The maximum duration of therapy is 10 days
The maximum dose is 200 mg
trimethoprim: they may increase the neutropenic effect of amodiaquine
trimethoprim: they may enhance the serum concentration of phenytoin
trimethoprim may increase serum concentrations of procainamide
fosphenytoin: they may diminish the serum concentration of trimethoprim
trimethoprim: they may enhance the serum concentration of dofetilide
may enhance the toxic effect of methotrexate, avoid combination
may enhance the toxic effect of trimetrexate, avoid combination
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
trimethoprim: they may increase the toxic effect of amantadine
trimethoprim: they may increase the myelosuppressive effect of azathioprine
trimethoprim: they may enhance the serum concentration of dapsone
trimethoprim: they may enhance the serum concentration of digoxin
trimethoprim: they may increase the hyperkalemic effect of eplerenone
trimethoprim: they may enhance the serum concentration of lamivudine
trimethoprim: they may increase the toxic effect of memantine
trimethoprim: they may increase the myelosuppressive effect of mercaptopurine
trimethoprim: they may enhance the serum concentration of pralatrexate
trimethoprim: they may diminish the serum concentration of sapropterin
trimethoprim: they may increase the hyperkalemic effect of spironolactone
trimethoprim: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
trimethoprim: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
trimethoprim: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
trimethoprim: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
trimethoprim: they may increase the hyperkalemic effect of Angiotensin II Receptor Blockers
may decrease trimethoprim elimination, raising serum levels
may increase the toxic effect of amantadine
may increase the CNS depressant effect of CNS Depressants
rifampin: they may diminish the serum concentration of trimethoprim
zidovudine: they may enhance the neutropenic effect of trimethoprim
may enhance the effect of the other by cationic drug competition for renal tubular clearance
Adverse drug reactions:
Frequency defined
1-10%
Rash
Urticaria
<0.01%
Photosensitivity
Angioedema
Exfoliative dermatitis
fixed drug eruption
Erythema multiforme
Erythema nodosum
Stevens-Johnson syndrome
toxic epidermal necrolysis (Lyell’s Syndrome)
bullous dermatitis
Purpura
Allergic vasculitis
Pregnancy warnings:
AU TGA pregnancy category: B3
US FDA pregnancy category: Not assigned.
Breastfeeding warnings:
The release of the drug into the human breastmilk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: trimethoprim (Rx)
Pronunciation: trye-METH-oh-prim
Why do we use trimethoprim?
trimethoprim is an antibiotic drug used to treat bladder, renal infections, or ear infections that are caused by certain bacteria.