ulecaciclib

Action and Spectrum

Actions and Spectrum:  

It has high selectivity and potency against CDK4 and CDK6. It crosses the blood-brain barrier to distinguish it from approved inhibitors.  

Drug Interaction

Adverse Reaction

Limited data is available 

Black Box Warning

Black box warning  

None  

Contraindication / Caution

Contraindication/Caution:  

Contraindications  

Hypersensitivity  

Cautions  

Renal impairment  

Hepatic impairment  

Drug interactions 

Pregnancy   

Pregnancy / Lactation

Pregnancy Warnings: 

Pregnancy category: N/A 

Lactation: Excretion of the drug into the human breast milk is unknown 

Pregnancy categories: 

• Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester. 
• Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology:  

The blood-brain barrier is a protective barrier which can prevent the entry of substances into the brain. Its ability to overcome this barrier enhances its potential effectiveness in addressing cancers within the central nervous system.  

Pharmacodynamics: 

Limited information is available.  

Pharmacokinetics:  

Limited information is available on ADME.  

Adminstartion

Administration:  

The route of administration is not well known.  

Patient Information Leaflet

Patient information leaflet  

Generic Name: ulecaciclib   

Why do we use ulecaciclib?  

It is an investigational drug indicated for treatment of glioblastoma multiforme (GBM) and brain metastases.