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Brand Name :
N/A
Synonyms :
upleganan
Class :
Antibiotic, Anti-Microbial
Brand Name :
N/A
Synonyms :
upleganan
Class :
Antibiotic, Anti-Microbial
Dosage Forms & Strengths Â
Injectable solution (IV/SC) Â
0.125 mg/kg Â
Pseudomonas aeruginosa infection and Enterobacteriaceae infection (off-label)
This intravenous (IV) drug (dose studied: 0.125 mg/kg) is undergoing phase I trial study where it is being investigated for the treatment of infections caused due to Pseudomonas aeruginosa and Enterobacteriaceae (gram -ve infections, bacteria)
:
Dose Adjustments
Limited data is available
Safety and efficacy are not established.Â
Refer to the adult dosingÂ
Actions and Spectrum: Â
Actions: Â
Upleganan fights multidrug-resistant Gram-negative bacteria effectively. The minimum inhibitory concentration of the drug against Acinetobacter baumannii and Pseudomonas aeruginosa is determined to be 0.125 mg/L.Â
Spectrum: Â
Upleganan shows potent antimicrobial effects on Gram-negative bacteria.Â
Limited data is availableÂ
Black box warning Â
Limited data is availableÂ
Contraindication/Caution: Â
Contraindications Â
Hypersensitivity Â
Cautions Â
Renal impairment Â
Hepatic impairment Â
Pregnancy & breastfeeding Â
Pregnancy consideration:  Â
No data is available regarding the administration of the drug during pregnancy. Â
Breastfeeding warnings:  Â
No data is available regarding the excretion of drug in breast milk. Â
Pregnancy category: Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. Â
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. Â
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    Â
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    Â
Category N: No data is available for the drug under this category. Â
Pharmacology: Â
Pfizer is testing upleganan in Phase I for Enterobacteriaceae infections. The Phase II entry guideline is a 70% Phase I success rate for such medicines.Â
Pharmacodynamics: Â
Upleganan treatment reduces Pa14 and NCTC13301 load in lung tissue and thigh model of neutropenic mice.Â
Pharmacokinetics: Â
Limited data is available Â
Administration: Â
The route of administration is Intravenous & subcutaneous.Â
Patient information leaflet Â
Generic Name: upleganan Â
Why do we use upleganan? Â
Upleganan targets gram-negative bacterial infections like Pseudomonas aeruginosa, Acinetobacter baumanii, & carbapenem-resistant Enterobacteriaceae.Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
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