- March 15, 2022
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Brand Name :
Synonyms :
Class :
Indicated for Angina
Immediate release-80 mg orally three times a day initially, usual dose range 80-120 mg orally three times a day. It should not exceed 480 mg daily.
Extended-release(Covera-HS)- 180 mg every day orally at bedtime as an initial dose.
Maintenance dose-180-540 mg every day orally at bedtime.
Paroxysmal Supraventricular Tachycardia and Chronic Atrial Fibrillation
Immediate release-240-480 mg every day orally in divided doses three-four times a day.
Atrial Fibrillation or Flutter and Supraventricular Arrhythmia
2.5-5 mg intravenously over 2 min; after 15-30 min, 5-10 mg dose may be repeated.
Or
0.075-0.15mg/kg (should not exceed 10 mg) intravenously over 2 min; after 30 min, the dose may be repeated.
Tardive Dyskinesia
40 mg orally three times a day may enhance the dose up to 120 mg three times a day.
Migraine as off-label
As prophylaxis 160-320 mg orally three-four times a day.
Hypertension
Immediate release
Initial dose:80 mg orally three times a day.
Maintenance dose: 80-320 mg orally two times a day.
Extended-release
Isoptin SR, Calan-180 mg every day orally in the morning (if the patient is elderly,120 mg every day); for desired therapeutic response, the dose may enhance to 240 mg every day and then 360 mg every day (i.e., 180 mg two times a day or 240 mg at morning time and 120 mg at evening time)
Verelan-180 mg every day orally in the morning (if the patient is elderly,120 mg every day); for desired therapeutic response, the dose may enhance to 240 mg every day and then 120 mg every day at weekly intervals, should not exceed 480 mg every day.
Covera-HS-180 mg every day orally at bedtime (if the patient is elderly,120 mg every day); for desired therapeutic response, the dose may enhance to 240 mg every day and then 120 mg every day at weekly intervals, should not exceed 480 mg every day.
Verelan PM-200 mg every day orally at bedtime (if the patient is elderly,100 mg every day); the dose may be enhanced by 100 mg every day at weekly intervals, and should not exceed 400 mg every day.
supraventricular tachycardia (SVT)
Age 1-15 years
0.1-0.3 mg/kg (should not exceed 5 mg) intravenously over 2 min; after that second dose may be given after 30 min (should not exceed 10 mg).
Or
4-8 mg/kg every day orally in divided doses three times a day.
Indicated for Angina
Immediate release-80 mg orally three times a day initially, usual dose range 80-120 mg orally three times a day. It should not exceed 480 mg daily.
Extended-release (Covera-HS)- 180 mg every day orally at bedtime as an initial dose.
Maintenance dose-180-540 mg every day orally at bedtime.
Hypertension
Immediate release
Initial dose:80 mg orally three times a day.
Maintenance dose: 80-320 mg orally two times a day.
Extended-release
Verelan PM-100 mg every day orally at bed time.
Covera-HS-180 mg every day orally at bed time.
Isoptin SR, Calan SR, Verelan-120 mg every day orally in the morning.
Note:
Generally, low doses are warranted, and based on clinical response dose may be adjusted.
It may enhance serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance hypotensive effect when combined with Blood Pressure Lowering Agents
verapamil may increase the serum concentration when combined with Talazoparib
CYP3A strong enhancers of the small intestine may reduce the bioavailability of verapamil
verapamil increases the effect of entrectinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
verapamil increases the effect of encorafenib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may increase toxicity of each other by unspecified interaction mechanism
may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter
it reduces the efficacy of metformin
may diminish the metabolism of verapamil
It may enhance the effect when combined with cannabidiol by affecting CYP3A4 metabolism
verapamil: they may diminish the serum concentration of CYP3A4 Inducers
verapamil: they may diminish the serum concentration of CYP3A4 Inducers
verapamil: they may diminish the serum concentration of CYP3A4 Inducers
verapamil: they may diminish the serum concentration of CYP3A4 Inducers
verapamil: they may diminish the serum concentration of CYP3A4 Inducers
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
It may enhance the serum concentration when combined with CYP3A4 Substrates
when bromazepam and verapamil are used together, there is a potential reduction in the bromazepam's metabolism
when both drugs are combined, there may be a reduced metabolism of erlotinib
increase the therapeutic effect of daunorubicin by P-glycoprotein efflux transporter
the effect of verapamil is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
may increase serum levels of docetaxel
fedratinib increases the effect of verapamil by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
increase the therapeutic effect of idarubicin by P-glycoprotein efflux transporter
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
it increases the effect or level of finasteride by altering the intestinal/hepatic enzyme CYP3A4 metabolism
it increases the effect or level of dutasteride by altering the intestinal/hepatic enzyme CYP3A4 metabolism
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