warfarin

DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Adverse effects  

Frequency defined:   

1-10% 

Cholesterol embolism syndrome 

Calciphylaxis 

Hemorrhage 

<1% 

Dermatitis 

Vasculitis 

Hepatitis 

Alopecia 

Avoid neonates and infants less than 4 months old due to a higher risk of bleeding. 

Pregnancy consideration: Category X (US FDA)  

Lactation: The presence of the drug in human breast milk is unknown.  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Patient information leaflet 

Generic Name: Warfarin (Rx) 

Pronounced: [WAR-far-in]  

Why do we use warfarin? 

Warfarin belongs to the class of anti-coagulant. It is used to reduce the formation of blood clots in veins and arteries, thereby reducing the risk of heart attack or stroke.