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Brand Name :
N/A
Synonyms :
zandelisib
Class :
Selective PI3K-delta inhibitor
Brand Name :
N/A
Synonyms :
zandelisib
Class :
Selective PI3K-delta inhibitor
Dosage Forms & Strengths
the drug is under investigation for cancers like hematologic malignancies
It is under investigation for its potential use in the treatment of various cancers, including hematologic malignancies
Not determined
Refer to adult dosing
Actions and Spectrum
Zandelisib inhibits the phosphoinositide 3 kinase that plays a role in cell growth and proliferation.
Frequency not defined
None
Black Box Warning
There is no black box warning
Contraindication/Caution:
There are specific contraindications
Pregnancy/Lactation
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Zandelisib acts by blocking PI3K delta, which is found in leukocytes and has a role in B-cell proliferation.
Pharmacodynamics
PI3K inhibitors regulates the immune cells and inhibits the P13K delta that plays a role in immune cell regulation.
Pharmacokinetics
Limited information available on ADME.
Administration
Zandelisib is under investigation and its administration is not known.
Patient information leaflet
Generic Name: zandelisib
Why do we use zandelisib?
Zandelisib is under investigation for the efficacy in non-Hodgkin lymphoma subtypes and chronic lymphocytic leukemia.
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