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Brand Name :
N/A
Synonyms :
zavondemstat
Class :
Antineoplastic, KDM4D inhibitor, small molecules
Brand Name :
N/A
Synonyms :
zavondemstat
Class :
Antineoplastic, KDM4D inhibitor, small molecules
Dosage Forms & Strengths
It is used as an investigational and research use only
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
Actions and Spectrum:
Actions:
Antineoplastic efficacy is exhibited by zavondemstat, a KDM4D (histone lysine demethylase 4D) inhibitor.
Spectrum:
Zavondemstat is a likely drug that stops a key enzyme called lysine-specific demethylase 1 (LSD1). LSD1 plays a big role in how cancers develop and grow. By blocking this enzyme, Zavondemstat changes the epigenetic settings in cells. It makes it harder for cancer cells to keep dividing and spreading. This epigenetic shift creates an unfriendly environment for cancer cells. Early tests in labs have shown that Zavondemstat works against many types of cancers. Scientists are now very interested in testing it in clinical trials. Zavondemstat offers a promising new way to treat cancer. It uses epigenetic controls to disrupt how cancer cells behave. As more studies happen, Zavondemstat could become an innovative new cancer treatment with great potential.
Limited data is available
Black Box Warning:
Limited data is available
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Zavondemstat, known as QC8222 or TACH 101, aims at a protein called histone lysine demethylase 4D (KDM4D). KDM4D controls gene expression by changing histone proteins. Zavondemstat hinders KDM4D, disrupting this control, potentially altering gene expression patterns. Abnormal gene expression can cause diseases like cancer. So, Zavondemstat’s ability to target KDM4D shows promise as a cancer treatment approach.
Pharmacodynamics:
This medicine might help fight cancer. It blocks an enzyme called KDM4D. Blocking this enzyme changes how genes are turned on and off. These changes impact cell growth and development, which could stop cancer from spreading.
Pharmacokinetics:
Limited data is available
Limited data is available
Patient information leaflet
Generic Name: zavondemstat
Pronounced: zuh-VON-dem-stat
Why do we use zavondemstat?
Cancer is a complex disease. Zavondemstat works against it. It blocks enzymes promoting cancer growth. Zavondemstat acts as an epigenetic modifier, targeting LSD1, a key enzyme aiding spread of cancer cells. LSD1 inhibition by Zavondemstat alters epigenetic state, creating an environment hostile for cancer cell survival. Lab studies confirm its effectiveness across cancer types, sparking further clinical trials interest. Zavondemstat represents significant progress in innovative cancer therapy development, highlighting epigenetic regulation’s pivotal role in controlling abnormal cellular processes.
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