Action and Spectrum

Drug Interaction

Adverse Reaction

Frequency defined:

>10%

Headache

Dizziness

Sinusitis

GI disturbance

Myalgia

Malaise

UTI

vainitis

leucopenia

Jaundise

urticaria

<1%

Anaphylaxis

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pregnancy consideration: only preferred if conventional therapies do not work to treat asthma in pregnancy.

Lactation: Zileuton excretion in breast milk is not known.

Pregnancy category:

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women.
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category outweigh risks over benefits These category drugs should be prohibited for pregnant women.
• Category N: There is no data available for the drug under this category.

Pharmacology

Adminstartion

Patient Information Leaflet

Patient information leaflet

Generic Name: Zileuton

Pronounced: ZE-LE-U-TON

Why do we use zileuton?

Zileuton is used to treat asthma.