Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Normud, Zelmid
Synonyms :
zimelidine, zimelidine hydrochloride
Class :
Antidepressant, Selective Serotonin Reuptake Inhibitor
Brand Name :
Normud, Zelmid
Synonyms :
zimelidine, zimelidine hydrochloride
Class :
Antidepressant, Selective Serotonin Reuptake Inhibitor
Dosage Forms & StrengthsÂ
TabletÂ
200 mgÂ
400 mgÂ
It is indicated for the treatment of depression
The usual recommended dose for inpatients is 300 mg one time a day, and the usual dose for outpatients is 200 to 400 mg daily one time
Dose Adjustments
Limited data is available
Not determined Â
Refer to the adult dosing
when zimelidine and buflomedil are combined, there is a chance that the risk or intensity of bleeding will rise
the metabolism of dihydroergocristine can decrease when combined with zimelidine
amitriptylinoxide(Phase 4 Clinical Trials)Â
combining zimelidine with amitriptylinoxide may increase the chances of adverse effects
combining zimelidine with amobarbital may increase the chances of adverse effects
combining zimelidine with amoxapine may increase the chances of adverse effects
combining zimelidine with anagrelide may increase the chances of hemorrhage
when zimelidine is used together, imidazole salicylate may increase the risk of gastrointestinal bleeding
the rate of metabolism of tocofersolan may be reduced with zimelidine
combining with asunaprevir can lead to a decreased metabolism of zimelidine
the therapeutic efficacy of carbimazole can be diminished when used in combination with zimelidine
the metabolism of prenylamine may be reduced when coadministered with zimelidine
the coadministration of zimelidine with ivacaftor may result in a reduction in the metabolism of ivacaftor
the metabolism of amlodipine may be decreased when combined with zimelidine
the chances of serotonin syndrome may be increased when amphetamine is combined with zimelidine
the metabolism of amprenavir may be decreased when combined with zimelidine
combining zimelidine with antipyrine may increase the chances of gastrointestinal bleeding
when combined with butalbital, the risk or extent of adverse effects associated with zimelidine may be increased
Actions and Spectrum:Â
Zimelidine works as a strong and selective inhibitor of serotonin 5-HT uptake and SERT.Â
Frequency not definedÂ
NauseaÂ
Dry mouthÂ
Increased sweatingÂ
Dryness of nasal and pharyngeal membranesÂ
Black Box Warning:Â
None Â
Contraindication/Caution:Â
The drug is contraindicated in following situations:Â
HypersensitivityÂ
Â
Pregnancy Warnings:Â Â
Pregnancy category: N/AÂ Â
Lactation:Â Â
Excretion of the drug in human breast milk is unknown Â
Pregnancy Categories:Â Â Â Â
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.   Â
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.   Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.   Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.   Â
Category N: There is no data available for the drug under this category.
Pharmacology:Â
The mechanism involves a potent inhibition of synaptic cleft reuptake of serotonin including no impact on postsynaptic receptors.Â
Pharmacodynamics:Â
It will prevent the reuptake of serotonin at the neuronal membrane’s serotonin reuptake pump, which increases serotonin’s impact on 5HT1A autoreceptors.Â
Pharmacokinetics:Â
Limited information is available on ADME.Â
Administration:Â
Zimelidine was administered orally in the form of tablets or capsules. Â
Patient information leafletÂ
Generic Name: zimelidineÂ
Why do we use zimelidine?Â
Zimelidine as an antidepressant was indicated for the treatment of depression and mood disorders.Â
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