Can one dose inhibit and reverse the parasitic infection?
- Yes, if the drug crosses the BBB (blood-brain barrier), there could be reversibility
- Maybe, if the drug is administered in the early disease stage
- No, the parasitic infection leaves residue, and can relapse
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An investigational drug proved effective in eliminating the parasite that causes sleeping sickness from patients’ bodies with an early to intermediate infection in a small trial. The parasitic infection known as sleeping sickness, also known as human African trypanosomiasis, is transmitted by tsetse flies. Without treatment, it can be fatal and lead to psychosis, uncontrollable aggression, and debilitating sleep disturbance. The parasite may persist and pass the blood-brain barrier if untreated, infiltrating the central nervous system and resulting in severe symptoms.
Patients suffering from the nightmare sickness tend to live in some of the most remote regions of west and central Africa, where travel times to the hospital can take days. In the past, patients with advanced stages of the disease required intravenous drips in addition to routine jabs for at least seven days. The study promises a single-dose, oral treatment that removes the need for hospitalization, removes the need for complex or invasive diagnosis or disease staging, and requires minimal training.
https://www.news-medical.net/news/20221130/Study-shows-the-efficacy-of-new-single-dose-oral-treatment-for-sleeping-sickness.aspx
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