Canada May Lose Its Measles Elimination Status-A Warning for the U.S.
Canada is on the verge of losing its measles elimination status, just a few years after successfully ending the previous wave, due to an ongoing outbreak that has persisted for over a year. The outbreak began in October 2024 in New Brunswick and has since resulted in more than 5,000 reported cases and two infant […]
Real world implementation of AlcoChange, a smartphone digital therapeutic to improve outcomes from alcohol-related liver disease: protocol for an individually randomised parallel group controlled trial
Trials. 2025 Oct 31;26(1):456. doi: 10.1186/s13063-025-09005-3. ABSTRACT BACKGROUND: Deaths from alcohol-related liver disease (ARLD) are rising in the UK, representing a significant public health crisis. Effective interventions are urgently needed to reduce alcohol consumption and improve outcomes for individuals with ARLD. While behaviour change interventions (BCIs) are effective, their scalability is limited. Digital therapeutics offer […]
Evaluating the impact of digital therapy for male LUTS: insights from the BEST trial subgroup analysis
World J Urol. 2025 Nov 1;43(1):660. doi: 10.1007/s00345-025-06016-2. ABSTRACT PURPOSE: Men with lower urinary tract symptoms (LUTS) represent a heterogeneous patient population. The BEST trial investigated the effectiveness of a digital health application for male LUTS. This pre-specified subgroup analysis evaluated treatment effects based on key clinical characteristics and additionally reports micturition diary outcomes and […]
Preparation of Fe3O4@PMAA-N protein magnetic beads for antibody detection of SARS-CoV-2 based on indirect ELISA smartphone visual strategy
Mikrochim Acta. 2025 Nov 1;192(11):785. doi: 10.1007/s00604-025-07646-4. ABSTRACT A novel immunomagnetic bead was prepared and designed to be combined with a smartphone app for the rapid detection of SARS-CoV-2 antibody in serum. The nucleocapsid protein (N protein) of SARS-CoV-2 was immobilized on the prepared magnetic polymer microspheres (Fe3O4@PMAA) with core-shell structure by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimid/N-hydroxy succinimide (EDC/NHS) […]
Protective Effects of Cocoa Flavanols on Vascular Health After Extended Sedentary Behavior
A recent study from the University of Birmingham reveals that consuming foods rich in flavanols, like tea, apples, berries, and cocoa, can protect vascular health in males from the harmful effects of prolonged sitting. A study published in The Journal of Physiology highlights how simple dietary choices can help to overcome one of the most […]
Celltrion Gains FDA Green Light for Interchangeable Denosumab Biosimilars
Celltrion Inc. announced that the U.S. Food and Drug Administration (FDA) has granted approval for STOBOCLO® (denosumab-bmwo) and OSENVELT® (denosumab-bmwo) as interchangeable biosimilar products to their reference XGEVA® (denosumab) and PROLIA® (denosumab) for all approved indications. This approval became effective on October 29, 2025. This designation allows pharmacists to substitute these biosimilar products for their […]
Mapping Gluten Sensitivity Worldwide: Insights from a Systematic Review and Meta-Analysis
Non-coeliac gluten/wheat sensitivity (NCGWS) refers to gastrointestinal and extraintestinal symptoms triggered by gluten or wheat ingestion in people without coeliac disease or wheat allergy. Symptoms improve after wheat or gluten avoidance and recur upon re-exposure. The underlying mechanisms and biomarkers remain unclear, though awareness has been raised due to public interest in gluten-free diets. Diagnosing […]
Safe Patient Handling Musculoskeletal Injury-Prevention Smartphone App for Community Health Care Workers: Mixed Methods Feasibility Study
JMIR Form Res. 2025 Oct 31;9:e70681. doi: 10.2196/70681. ABSTRACT BACKGROUND: Safe patient handling is critical for reducing musculoskeletal injuries among health care workers; yet, community health care workers often face barriers such as limited access to training and real-time resources. OBJECTIVE: This study had three objectives: (1) provide detailed insights into the unmet needs of […]
Brief Digital Interventions for Psychological Distress: An AI-Enhanced Response-Adaptive Randomized Clinical Trial
JAMA Netw Open. 2025 Oct 1;8(10):e2540502. doi: 10.1001/jamanetworkopen.2025.40502. ABSTRACT IMPORTANCE: A large proportion of college students report experiencing psychological distress. Smartphone app-based interventions may alleviate distress, but their effectiveness across severity levels is unclear. Artificial intelligence (AI)-enhanced response-adaptive randomized clinical trials may offer an efficient method to evaluate competing interventions. OBJECTIVE: To compare the effectiveness […]
Detecting Perceived Unfair Treatment Among US College Students Using Mobile Sensing: Pilot Machine Learning Study
JMIR Form Res. 2025 Oct 31;9:e78657. doi: 10.2196/78657. ABSTRACT BACKGROUND: Experiences of unfair treatment on college campuses are linked to adverse mental and physical health outcomes, highlighting the need for interventions. However, detecting such experiences relies mainly on self-reports. No prior research has examined the feasibility of using mobile sensing via smartphones and wearables for […]
