Prognostic Accuracy of Clinical Indicators for Severe Maternal Outcomes After Postpartum Hemorrhage
Approximately 260,000 women die each year from childbirth and pregnancy complications, mainly from postpartum hemorrhage (PPH), specifically in low-income regions like South Asia and sub-Saharan Africa, because of limited access to care. While blood loss criteria for PPH exist, they may not accurately reflect individual risk due to physiological variations. The same volume of blood […]
Effectiveness, Engagement, and Safety of a Digital Therapeutic (CT-155/BI 3972080) for Treating Negative Symptoms in People With Schizophrenia: Protocol for the Phase 3 CONVOKE Randomized Controlled Trial
JMIR Res Protoc. 2025 Oct 7;14:e81293. doi: 10.2196/81293. ABSTRACT BACKGROUND: Negative symptoms of schizophrenia, such as lack of motivation, pleasure, social interest, and expression, are key contributors to functional impairments in people with schizophrenia. While psychosocial interventions have demonstrated efficacy, no Food and Drug Administration-approved pharmacotherapies exist specifically to target these symptoms. Evidence-based digital therapeutics […]
A Personalized and Smartphone-Based Serious Gaming App Targeting Cognitive Impairments in Alcohol Use Disorder: Double-Blinded, Randomized Controlled Efficacy Trial Among Outpatients
JMIR Ment Health. 2025 Oct 7;12:e67167. doi: 10.2196/67167. ABSTRACT BACKGROUND: Alcohol use disorder (AUD) is associated with cognitive impairments that are known to affect the outcomes of conventional treatment. Digital cognitive training programs have been examined as a possible way of addressing these overlooked challenges. Existing findings regarding the efficacy of such training programs are […]
Evaluation of Mobile Intermittent Fasting Applications in Chinese App Stores: Quality Evaluations and Content Analysis
JMIR Mhealth Uhealth. 2025 Oct 7;13:e66339. doi: 10.2196/66339. ABSTRACT BACKGROUND: Obesity and related disorders are rising globally, especially in China, where they are linked to chronic diseases like diabetes and cardiovascular issues. As intermittent fasting (IF) gains popularity for weight management, the use of IF apps has increased, yet their quality varies significantly. A systematic […]
Effectiveness and theory-based evaluation of a personalised digital intervention (EviBody®) for healthy and sustained lifestyle behaviours and well-being among adults: Study protocol for a real-world quasi-experimental study
PLoS One. 2025 Oct 7;20(10):e0333201. doi: 10.1371/journal.pone.0333201. eCollection 2025. ABSTRACT BACKGROUND: Digital interventions offering behaviour change support are warranted to prevent and treat non-communicable diseases, and have been evaluated rigorously in controlled settings. Effectivenss, factors influencing the uptake of scaled-up interventions-such as reach, received dose, usability and acceptability- and predictors and mediators of efficiency are […]
Promoting mental well-being among secondary school students in Vietnam using the Y-MIND app: A protocol for a hybrid type 2, sequence pre-post, quasi-experimental study
PLoS One. 2025 Oct 7;20(10):e0332875. doi: 10.1371/journal.pone.0332875. eCollection 2025. ABSTRACT This study is registered at ClinicalTrials.gov (NCT06753344). PMID:41056276 | DOI:10.1371/journal.pone.0332875
Hormones Shape the Brain: Menstrual Cycle Reveals Dynamic Structural Changes
Fluctuations in gonadal hormones, particularly progesterone and estradiol, regulate the menstrual cycle and affect brain structure, behavior, and function. These hormones exert their effects via widely distributed brain receptors. However, several cross-sectional studies comparing menstrual phases have revealed regional gray matter variations but fail to capture individual hormonal rhythms. Recent longitudinal neuroimaging research approaches offer […]
Gut and Oral Microbiome Dysbiosis in Pancreatic Cancer: Implications for Early Detection
Pancreatic cancer (PC) is an invasive malignancy with a poor prognosis. The 5-year survival rate is only about 10%, primarily due to the absence of a specific early diagnostic indicator and the late stage at which the disease is detected. Among its subtypes, pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of PC. PDAC […]
Promoting Physical Activity and Preventing Falls Among Older Adults in a Nursing Home Setting: Protocol for Development and Implementation of the BeSt Age Mobile App
JMIR Res Protoc. 2025 Oct 6;14:e74174. doi: 10.2196/74174. ABSTRACT BACKGROUND: Most nursing home residents do not meet physical activity guidelines. Many interventions to promote physical activity and prevent falls in nursing home residents have low adherence rates, lack a theoretical foundation, or require much time from staff for preparation or delivery. OBJECTIVE: This study aims […]
The relationship between social support and smartphone addiction among Chinese college students: the mediating role of loneliness and the moderating role of meaning in life
Front Public Health. 2025 Sep 18;13:1671800. doi: 10.3389/fpubh.2025.1671800. eCollection 2025. ABSTRACT BACKGROUND: Smartphone addiction has become a significant public health concern among Chinese college students, adversely affecting their academic performance, social interactions, and psychological well-being. Based on the social support buffering hypothesis and compensatory internet use theory, loneliness may mediate the relationship between social support […]
