SPP1 Identified as Key Driver of Aggressive Cell Fate and Metastasis in Pancreatic Cancer
A groundbreaking study published in Nature revealed the important role of secreted phosphoprotein 1 (SPP1), also known as osteopontin, in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). The research highlights how SPP1 promotes tumor aggressiveness and identifies potential treatment interventions targeting this protein. Pancreatic cancer is one of the cancers with the lowest chances of […]
Dissemination of Information on Selective Serotonin Reuptake Inhibitors on TikTok: Analytical Mixed Methods Study of Creator Types, Content Tone, and User Engagement
JMIR Ment Health. 2025 Sep 30;12:e77383. doi: 10.2196/77383. ABSTRACT BACKGROUND: TikTok [ByteDance] is a significant source of mental health-related content, including discussions on selective serotonin reuptake inhibitors (SSRIs). While the app fosters community building, its algorithm also amplifies misinformation as influencers without relevant expertise often dominate conversations about SSRIs. These videos frequently highlight personal experiences, […]
Professional Support Through a Tailor-Made Mobile App to Reduce Stress and Depressive Symptoms Among Family Caregivers of People With Dementia: Mixed Methods Pilot Study
JMIR Form Res. 2025 Sep 30;9:e75113. doi: 10.2196/75113. ABSTRACT BACKGROUND: Providing informal care to people with dementia living at home can be challenging and may cause caregiver stress and depression. Interventions delivered through mobile apps provide innovative solutions for community-based social care professionals to address the increasing support needs of family caregivers (FCs) of people […]
How Engagement Changes Over Time in a Digital Eating Disorder App: Observational Study
JMIR Mhealth Uhealth. 2025 Sep 30;13:e68824. doi: 10.2196/68824. ABSTRACT BACKGROUND: Engagement with digital mental health interventions is often measured as a summary-level variable and remains underresearched despite its importance for meaningful symptom change. This study deepens understanding of engagement in a digital eating disorder intervention, recovery record, by measuring engagement with unique components of the […]
Bedtime App-Guided Mindfulness Meditation in Patients With Insomnia: Mixed Methods Feasibility and Acceptability Pilot Study
JMIR Form Res. 2025 Sep 30;9:e67366. doi: 10.2196/67366. ABSTRACT BACKGROUND: While mindfulness meditation (MM) apps have gained popularity as a tool for promoting sleep, research focusing on bedtime mindfulness practice and app usage is limited. OBJECTIVE: As the first step toward understanding the efficacy and mechanisms of such bedtime practice and to inform future investigations, […]
Violence in the Workplace: Preparedness, Prevention, Response, and Recovery Strategies for Acute and Critical Care Nurses
Crit Care Nurse. 2025 Oct 1;45(5):28-45. doi: 10.4037/ccn2025799. ABSTRACT BACKGROUND: Workplace violence has been increasing in hospitals and has been associated with employee turnover and decreased productivity and quality of care. OBJECTIVE: To identify interventions acute and critical care nurses can employ to address workplace violence among patients and visitors. METHODS: The methods of Whittemore, […]
Smartphone-Based Mindfulness and Mentalization Ecological Momentary Interventions for Common Mental Health Problems: Pilot Randomized Controlled Trial
JMIR Ment Health. 2025 Sep 30;12:e79296. doi: 10.2196/79296. ABSTRACT BACKGROUND: Accessible ecological momentary interventions deliver brief, real-time support integrated into daily routines. Interpersonal dynamics and maladaptive coping mechanisms can contribute to an individual’s anxiety and depression. Both mindfulness and mentalization represent psychological constructs with the potential to mitigate the negative impact of interpersonal stressors. OBJECTIVE: […]
A Multimodal Approach to Transform Culture by Implementing AACN’s Healthy Work Environment Standards
Crit Care Nurse. 2025 Oct 1;45(5):e1-e9. doi: 10.4037/ccn2025911. ABSTRACT BACKGROUND: Organizational culture and work environment are important factors in retaining staff members and achieving good patient outcomes. The COVID-19 pandemic exacerbated existing challenges for nurses and the health care organizations employing them. LOCAL PROBLEM: Following the COVID-19 pandemic, the nursing staff turnover rate at Los […]
EU Commission Acts to Simplify Lifecycle Oversight of Medicines
The European Commission has published Guidelines to provide organizations and businesses with greater flexibility in updating and changing marketing approvals. The European Medicines Agency (EMA) and national regulators both collaborated with the commission for the development of new lifecycle management measures. The study emphasized the importance of adopting a risk-based and simplified approach to handling […]
Health Authorities Detect New World Screwworm in Mexico’s Nuevo Leon
Mexico has reported a new outbreak of New World screwworm (NWS) in Sabinas Hidalgo, Mexico, in the state of Nuevo Leo. This represents the furthest location to date where NWS has been detected and poses a significant threat to the livestock industry in the U.S. Sabinas Hidalgo is located on the high-traffic highway connecting Monterrey, […]
