Common Gene Variants in Meiosis Drive Human Recombination and Chromosome Segregation Errors
Errors in chromosome segregation during meiosis are a leading cause of early pregnancy loss or first-trimester miscarriage, which in part can be explained by the presence of an abnormal number of chromosomes in embryos, aneuploidy. Although the role of the abnormal crossover recombination in this process has been long established, the shared genetic basis linking […]
Development of a Mobile App (MyLepto App) to Improve Knowledge, Attitude, and Practice Regarding Leptospirosis Among Wet Market Workers in Selangor, Malaysia: Protocol for a Quasi-Experimental Study
JMIR Res Protoc. 2026 Jan 23;15:e75809. doi: 10.2196/75809. ABSTRACT BACKGROUND: Leptospirosis is the most common zoonotic cause of mortality, with most of its burden occurring in tropical regions and low-income countries. It is endemic in Southeast and South Asian nations. Leptospirosis outbreaks occur after natural disasters. In Malaysia, the e-notification system of the Communicable Diseases […]
SiQDs and [Ru(bpy)2(phen-NH2)]2+ based ratiometric fluorescence probe for point-of-care testing of 6PPD-quinone with 3D-printing portable devices
Anal Chim Acta. 2026 Feb 15;1387:345075. doi: 10.1016/j.aca.2026.345075. Epub 2026 Jan 7. ABSTRACT BACKGROUND: N-phenyl-N’-(1,3-dimethylbutyl)-p-phenylenediamine-quinone (6PPD-Q), an emerging pollutant, is a highly toxic chemical derived from tires, which have possible adverse effects on human health via the food chain. Despite the widespread occurrence of 6PPD-Q in the environment, methods for its detection remain relatively scarce. […]
Developing a Culturally Adapted Digital Health Application for Older Hispanic Adults With Type 2 Diabetes: Protocol for a Qualitative and Pilot Study
JMIR Res Protoc. 2026 Jan 23;15:e76294. doi: 10.2196/76294. ABSTRACT BACKGROUND: Over 40% of Hispanic individuals have below basic health literacy levels, significantly impacting their ability to manage chronic conditions such as type 2 diabetes (T2D). Chronic disease self-management, essential for improving adherence, is often hindered by modifiable factors such as health literacy. Ambulatory care clinical […]
Associations Between Perceived Discrimination Events and Next-Day Emotions Assessed Via Ecological Momentary Assessments
Stress Health. 2026 Feb;42(1):e70142. doi: 10.1002/smi.70142. ABSTRACT Discrimination, defined as the experience of unjustified or prejudicial treatment based on qualities such as race, age, gender, or sexual orientation, may negatively impact well-being. Prior research suggests that experiencing discrimination events is associated with higher negative affect. The purpose of this study was to use smartphone-based ecological […]
The Impact of AI-Based Educational Applications on University Students’ Piano Skills and Self-Efficacy
Int J Psychol. 2026 Apr;61(2):e70167. doi: 10.1002/ijop.70167. ABSTRACT The incorporation of AI-powered applications into music education is becoming increasingly important, as these tools can extend practice support beyond the session and provide rapid performance feedback. The current study investigated whether an app-assisted learning technique improves pianists’ performance skills and self-efficacy compared to traditional instruction. Participants […]
Researchers Identify a Brain Lysosomal Atlas That Reclassifies SLC45A1-Associated Disease as a Lysosomal Disorder
Lysosomes are membrane-bound organelles essential for cellular homeostasis, macromolecule degradation, and organelle turnover. These include luminal hydrolases and membrane-associated regulators. They regulate pH balance, trafficking, degradation, and fusion. Lysosomes also include energy and nutrient sensing. Key pathways include AMPK and mTORC1. They store metals, amino acids, and cholesterol. Lysosomal defects cause lysosomal storage disorders. They […]
SCIENCE Study Reveals Non-Surgical Care Is Safer, Cheaper, and Effective for Kids’ Elbow Fractures
Displaced medical epicondyle fractures account for about 10% of pediatric elbow injuries, most commonly affecting children aged 10-12 years. These fractures are frequently associated with elbow dissociation. Management of this condition remains challenging, with non-operative treatment or surgical fixation. Most existing studies support both approaches, but high-quality evidence is limited. A recent SCIENCE study published […]
Material-Specific X-Ray Virtual Histology by Modulation-Based Imaging
Histopathology is the gold standard for disease diagnosis through microscopic examination of tissue. Conventional methods depend on physical sectioning and two-dimensional (2D) analysis, which can introduce artifacts and obscure three-dimensional (3D) tissue architecture. Although computational reconstruction from serial sections is possible, it is labour-intensive and susceptible to registration errors. X-ray-based virtual histology offers a complementary, […]
Implementation of Digital Device-Assisted and Nurse-Led Case Management to Promote Self-Management in Adults With Noncommunicable Diseases: Protocol for a Single-Arm Intervention Study
JMIR Res Protoc. 2026 Jan 22;15:e80083. doi: 10.2196/80083. ABSTRACT BACKGROUND: Self-management plays a vital role in noncommunicable disease prevention and control. However, it has been challenging for patients and their caregivers to identify how much their lifestyle affects their health and what level of effort they should make to reduce cardiovascular disease (CVD) risks in […]
